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IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling

Qiu AW, Bian Z, Mao PA, Liu QH

Diabetic retinopathy (DR), one of the most serious complications of diabetes, has been associated with inflammatory processes. We have recently reported that interleukin (IL)-17A, a proinflammatory cytokine, is increased in...
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Evaluation of a tyrosine kinase peptide microarray for tyrosine kinase inhibitor therapy selection in cancer

Labots M, Gotink KJ, Dekker H, Azijli K, van der Mijn JC, Huijts CM, Piersma SR, Jiménez C, Verheul HM

Personalized cancer medicine aims to accurately predict the response of individual patients to targeted therapies, including tyrosine kinase inhibitors (TKIs). Clinical implementation of this concept requires a robust selection tool....
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The maintenance ability and Ca²⁺ availability of skeletal muscle are enhanced by sildenafil

Huang M, Lee KJ, Kim KJ, Ahn MK, Cho CH, Kim DH, Lee EH

Sildenafil relaxes vascular smooth muscle cells and is used to treat pulmonary artery hypertension as well as erectile dysfunction. However, the effectiveness of sildenafil on skeletal muscle and the benefit...
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Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity

Jeon JH, Kim DK, Shin Y, Kim HY, Song B, Lee EY, Kim JK, You HJ, Cheong H, Shin DH, Kim ST, Cheong JH, Kim SY, Jang H

A small proportion of cancer cells have stem-cell-like properties, are resistant to standard therapy and are associated with a poor prognosis. The metabolism of such drug-resistant cells differs from that...
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Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS

Park JH, Park HS, Hong S, Kang S

Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease characterized by the loss of motor neurons in the spinal cord and brain. Mutations in Cu/Zn superoxide dismutase 1 (SOD1)...
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C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive β-catenin/BAMBI signaling

Lee S, Lee MJ, Zhang J, Yu GR, Kim DG

C-terminal-truncated hepatitis B virus (HBV) X (HBx) (ctHBX) is frequently detected in hepatocellular carcinoma (HCC) through HBV integration into the host genome. However, the molecular mechanisms underlying ctHBx-associated oncogenic signaling...
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Optimization of the optical transparency of rodent tissues by modified PACT-based passive clearing

Woo J, Lee M, Seo JM, Park HS, Cho YE

Recently, a bio-electrochemical technique known as CLARITY was reported for three-dimensional phenotype mapping within transparent tissues, allowing clearer whole-body and organ visualization with CB-perfusion (CUBIC) and leading to the development...
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