- Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch
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Yang JH, Song TY, Jo C, Park J, Lee HY, Song I, Hong S, Jung KY, Kim J, Han JW, Youn HD, Cho EJ
- KMID: 2361539
- Exp Mol Med.
- 2016 Aug;48(8):e252.
- doi: 10.1038/emm.2016.68
Replication-independent incorporation of variant histone H3.3 has a profound impact on chromatin function and numerous cellular processes, including the differentiation of muscle cells. The histone chaperone HIRA and H3.3 have... -
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- The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
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Park YY, Nam HJ, Do M, Lee JH
- KMID: 2361537
- Exp Mol Med.
- 2016 Aug;48(8):e250.
- doi: 10.1038/emm.2016.61
RSK2, also known as RPS6KA3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 3), is a downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription,... -
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- Targeted exome sequencing resolves allelic and the genetic heterogeneity in the genetic diagnosis of nephronophthisis-related ciliopathy
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Kang HG, Lee HK, Ahn YH, Joung JG, Nam J, Kim NK, Ko JM, Cho MH, Shin JI, Kim J, Park HW, Park YS, Ha IS, Chung WY, Lee DY, Kim SY, Park WY, Cheong HI
- KMID: 2361538
- Exp Mol Med.
- 2016 Aug;48(8):e251.
- doi: 10.1038/emm.2016.63
Nephronophthisis-related ciliopathy (NPHP-RC) is a common genetic cause of end-stage renal failure during childhood and adolescence and exhibits an autosomal recessive pattern of inheritance. Genetic diagnosis is quite limited owing... -
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- Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
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Heo HJ, Kim HK, Youm JB, Cho SW, Song IS, Lee SY, Ko TH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2361541
- Exp Mol Med.
- 2016 Aug;48(8):e254.
- doi: 10.1038/emm.2016.70
Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitochondrial regulators that manage the... -
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- Sarcoplasmic reticulum Ca²⺠ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells
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Hong CY, Lee HJ, Choi NR, Jung SH, Vo MC, Hoang MD, Kim HJ, Lee JJ
- KMID: 2361540
- Exp Mol Med.
- 2016 Aug;48(8):e253.
- doi: 10.1038/emm.2016.69
The migration of dendritic cells (DCs) to secondary lymphoid organs depends on chemoattraction through the interaction of the chemokine receptors with chemokines. However, the mechanism of how lymphoid chemokines attract... -
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- Crucial role of HMGA1 in the self-renewal and drug resistance of ovarian cancer stem cells
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Kim DK, Seo EJ, Choi EJ, Lee SI, Kwon YW, Jang IH, Kim SC, Kim KH, Suh DS, Seong-Jang K, Lee SC, Kim JH
- KMID: 2361542
- Exp Mol Med.
- 2016 Aug;48(8):e255.
- doi: 10.1038/emm.2016.73
Cancer stem cells are a subpopulation of cancer cells characterized by self-renewal ability, tumorigenesis and drug resistance. The aim of this study was to investigate the role of HMGA1, a... -
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