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Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG

p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological...
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Serum DKK-1 level in the development of ankylosing spondylitis and rheumatic arthritis: a meta-analysis

Zhang L, Ouyang H, Xie Z, Liang ZH, Wu XW

To explore the association of serum Dickkopf-1 (DKK-1) levels with the development of ankylosing spondylitis (AS) and rheumatic arthritis (RA) in humans, databases including PubMed, EBSCO, Springerlink, Ovid, WANFANG and...
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Differentiation of human CD14+ monocytes: an experimental investigation of the optimal culture medium and evidence of a lack of differentiation along the endothelial line

Safi W, Kuehnl A, Nüssler A, Eckstein H, Pelisek J

The aim of this study was to determine the optimal culturing media for human CD14+ monocytes and to evaluate whether these cells are capable of differentiating into vascular endothelial cells....
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miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells

Cho YM, Kim TM, Kim DH, Kim DH, Jeong SW, Kwon OJ

Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by...
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Myosin heavy chain is stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle

Hong J, Park JS, Lee H, Jeong J, Yun HH, Kim HY, Ko YG, Lee JH

BCL-2 interacting cell death suppressor (BIS), which is ubiquitously expressed, has important roles in various cellular processes, such as apoptosis, the cellular stress response, migration and invasion and protein quality...
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AMPK activators: mechanisms of action and physiological activities

Kim J, Yang G, Kim Y, Kim J, Ha J

AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of...
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