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Analyses of the TCR repertoire of MHC class II-restricted innate CD4+ T cells

Kang BH, Min HS, Lee YJ, Choi B, Kim EJ, Lee J, Kim JR, Cho KH, Kim TJ, Jung KC, Park SH

Analysis of the T-cell receptor (TCR) repertoire of innate CD4+ T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4+ T cells) is essential for...
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Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and alpha-synuclein aggregation

Bae EJ, Yang NY, Lee C, Lee HJ, Kim S, Sardi SP, Lee SJ

Lysosomal dysfunction is a common pathological feature of neurodegenerative diseases. GTP-binding protein type A1 (GBA1) encodes beta-glucocerebrosidase 1 (GCase 1), a lysosomal hydrolase. Homozygous mutations in GBA1 cause Gaucher disease,...
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Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation

Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY

The Wnt/beta-catenin pathway has a role in osteoblast differentiation and bone formation. We screened 100 plant extracts and identified an extract from Euodia sutchuenensis Dode (ESD) leaf and young branch...
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Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives

Tong LM, Fong H, Huang Y

Underlying cognitive declines in Alzheimer's disease (AD) are the result of neuron and neuronal process losses due to a wide range of factors. To date, all efforts to develop therapies...
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The role of mitochondrial DNA mutation on neurodegenerative diseases

Cha MY, Kim DK, Mook-Jung

Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may...
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Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome

Kim B, Feldman EL

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity, diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the development and progression of Alzheimer's disease...
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Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease

Musiek ES, Xiong DD, Holtzman D

Disturbances in the sleep-wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes. Recent evidence...
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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

Ciechanover A, Kwon YT

Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the...
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Special issue on neurodegenerative diseases and their therapeutic approaches

Kim J, Mook-Jung

No abstract available.
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Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells

Park S, Kim JK, Oh CJ, Choi SH, Jeon JH, Lee IK

Scoparone, which is a major constituent of Artemisia capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, and it is used for the traditional treatment of...
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Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases

Choi UY, Kang JS, Hwang YS, Kim YJ

The study of antiviral pathways to reveal methods for the effective response and clearance of virus is closely related to understanding interferon (IFN) signaling and its downstream target genes, IFN-stimulated...
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