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Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension

Kim JD, Lee A, Choi J, Park Y, Kang H, Chang W, Lee MS, Kim J

Pulmonary arterial hypertension (PAH) is a rare but progressive and currently incurable disease, which is characterized by vascular remodeling in association with muscularization of the arterioles, medial thickening and plexiform...
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Fetal hematopoietic stem cells express MFG-E8 during mouse embryogenesis

Lee J, Choi BI, Park SY, An SY, Han J, Kim JH

The milk fat globule-EGF-factor 8 protein (MFG-E8) has been identified in various tissues, where it has an important role in intercellular interactions, cellular migration, and neovascularization. Previous studies showed that...
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Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics

Park HJ, Sohn JH, Kim YJ, Park YH, Han H, Park KH, Lee K, Choi H, Um K, Choi IH, Park JW, Lee JH

Silica nanoparticles (SNPs) are widely used in many scientific and industrial fields despite the lack of proper evaluation of their potential toxicity. This study examined the effects of acute exposure...
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MicroRNA-103a-3p controls proliferation and osteogenic differentiation of human adipose tissue-derived stromal cells

Kim DS, Lee SY, Lee JH, Bae YC, Jung JS

The elucidation of the molecular mechanisms underlying the differentiation and proliferation of human adipose tissue-derived stromal cells (hADSCs) represents a critical step in the development of hADSCs-based cellular therapies. To...
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Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IkappaB/NF-kappaB, in atherosclerotic cell model

Qiu L, Xu R, Wang S, Li S, Sheng H, Wu J, Qu Y

Pentraxin 3 (PTX3) was identified as a marker of the inflammatory response and overexpressed in various tissues and cells related to cardiovascular disease. Honokiol, an active component isolated from the...
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