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Activation of KRAS promotes the mesenchymal features of basal-type breast cancer

Kim RK, Suh Y, Yoo KC, Cui YH, Kim H, Kim MJ, Kim IG, Lee SJ

Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of...
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Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target

Tse E, Kwong YL

Epstein Barr virus (EBV)-associated lymphoproliferative diseases (LPDs) express all EBV latent antigens (type III latency) in immunodeficient patients and limited antigens (type I and II latencies) in immunocompetent patients. Post-transplantation...
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Modeling EBV infection and pathogenesis in new-generation humanized mice

Fujiwara S, Imadome KI, Takei M

The development of highly immunodeficient mouse strains has allowed the reconstitution of functional human immune system components in mice. New-generation humanized mice generated in this manner have been extensively used...
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Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma

Gulley ML

A small set of gastric adenocarcinomas (9%) harbor Epstein-Barr virus (EBV) DNA within malignant cells, and the virus is not an innocent bystander but rather is intimately linked to pathogenesis...
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Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders

Cai Q, Chen K, Young KH

Epstein-Barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent infections that result in a variety of human diseases, including lymphoproliferative disorders. The oncogenic potential of Epstein-Barr virus...
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EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management

Ok CY, Li L, Young KH

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, affecting >90% of the adult population. EBV targets B-lymphocytes and achieves latent infection in a circular episomal form. Different latency patterns are recognized...
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Epstein-Barr virus latent genes

Kang MS, Kieff E

Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited...
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EBV and human cancer

Ko YH

No abstract available.
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BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity

Kim DH, Do MS

Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first...
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Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells

Kim BS, Kang HJ, Park JY, Lee J

Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar...
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