- EBV and human cancer
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Ko YH
- KMID: 2155395
- Exp Mol Med.
- 2015 Jan;47(1):e130.
- doi: 10.1038/emm.2014.109
No abstract available. -
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- Modeling EBV infection and pathogenesis in new-generation humanized mice
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Fujiwara S, Imadome KI, Takei M
- KMID: 2155400
- Exp Mol Med.
- 2015 Jan;47(1):e135.
- doi: 10.1038/emm.2014.88
The development of highly immunodeficient mouse strains has allowed the reconstitution of functional human immune system components in mice. New-generation humanized mice generated in this manner have been extensively used... -
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- Activation of KRAS promotes the mesenchymal features of basal-type breast cancer
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Kim RK, Suh Y, Yoo KC, Cui YH, Kim H, Kim MJ, Kim IG, Lee SJ
- KMID: 2155402
- Exp Mol Med.
- 2015 Jan;47(1):e137.
- doi: 10.1038/emm.2014.99
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of... -
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- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
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Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
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- Epstein-Barr virus latent genes
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Kang MS, Kieff E
- KMID: 2155396
- Exp Mol Med.
- 2015 Jan;47(1):e131.
- doi: 10.1038/emm.2014.84
Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited... -
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- Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target
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Tse E, Kwong YL
- KMID: 2155401
- Exp Mol Med.
- 2015 Jan;47(1):e136.
- doi: 10.1038/emm.2014.102
Epstein Barr virus (EBV)-associated lymphoproliferative diseases (LPDs) express all EBV latent antigens (type III latency) in immunodeficient patients and limited antigens (type I and II latencies) in immunocompetent patients. Post-transplantation... -
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- Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders
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Cai Q, Chen K, Young KH
- KMID: 2155398
- Exp Mol Med.
- 2015 Jan;47(1):e133.
- doi: 10.1038/emm.2014.105
Epstein-Barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent infections that result in a variety of human diseases, including lymphoproliferative disorders. The oncogenic potential of Epstein-Barr virus... -
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- Genomic assays for Epstein-Barr virus-positive gastric adenocarcinoma
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Gulley ML
- KMID: 2155399
- Exp Mol Med.
- 2015 Jan;47(1):e134.
- doi: 10.1038/emm.2014.93
A small set of gastric adenocarcinomas (9%) harbor Epstein-Barr virus (EBV) DNA within malignant cells, and the virus is not an innocent bystander but rather is intimately linked to pathogenesis... -
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- BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
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Kim DH, Do MS
- KMID: 2155394
- Exp Mol Med.
- 2015 Jan;47(1):e129.
- doi: 10.1038/emm.2014.98
Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first... -
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- EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management
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Ok CY, Li L, Young KH
- KMID: 2155397
- Exp Mol Med.
- 2015 Jan;47(1):e132.
- doi: 10.1038/emm.2014.82
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, affecting >90% of the adult population. EBV targets B-lymphocytes and achieves latent infection in a circular episomal form. Different latency patterns are recognized... -
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