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The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5

Park MH, Choi KY, Min DS

Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase...
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Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1

Song MK, Lee ZH, Kim HH

Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone...
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The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma

Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH

Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is...
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Crosstalk between FLS and chondrocytes is regulated by HIF-2alpha-mediated cytokines in arthritis

Huh YH, Lee G, Song WH, Koh JT, Ryu JH

Rheumatoid arthritis (RA) and osteoarthritis (OA), two common types of arthritis, affect the joints mainly by targeting the synovium and cartilage. Increasing evidence indicates that a significant network connects synovitis...
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