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Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced beta-cell damage and the development of type 1 diabetes

Bae UJ, Jang HY, Lim JM, Hua L, Ryu JH, Park BH

The axis of nuclear factor kappaB (NF-kappaB)-inducible NO synthase (iNOS)-nitric oxide plays a key role in cytokine- and streptozotocin-mediated pancreatic beta-cell damage. In this study, we investigated the effects of...
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Polyubiquitin chain-dependent protein degradation in TRIM30 cytoplasmic bodies

Choi UY, Choi WY, Hur JY, Kim YJ

Viral infection induces numerous tripartite motif (TRIM) proteins to control antiviral immune signaling and viral replication. Particularly, SPRY-containing TRIM proteins are found only in vertebrates and they control target protein...
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Gephyrin: a central GABAergic synapse organizer

Choii G, Ko J

Gephyrin is a central element that anchors, clusters and stabilizes glycine and gamma-aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self-assembles into a hexagonal lattice...
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Effects of MBL2 polymorphisms in patients with diisocyanate-induced occupational asthma

Kim SH, Bae SJ, Palikhe S, Ye YM, Park HS

Diisocyanate (DI) is the most common cause of occupational asthma (OA) in Korea. Mannose-binding lectin (MBL) initiates the lectin complement activation pathway following oxidative stress and plays an important role...
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MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage

Lee AJ, Cho KJ, Kim JH

Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6...
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Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation

Choi KY, Yoo M, Han JH

The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know...
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