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A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met

Chaudhary , Cho MG, Nguyen TT, Park KS, Kwon MH, Lee JH

The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of some cells irrespective of ligand stimulation, but the responsible nuclear localization signal (NLS) has not...
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Chronic stress enhances progression of periodontitis via alpha1-adrenergic signaling: a potential target for periodontal disease therapy

Lu H, Xu M, Wang F, Liu S, Gu J, Lin S

This study assessed the roles of chronic stress (CS) in the stimulation of the sympathetic nervous system and explored the underlying mechanisms of periodontitis. Using an animal model of periodontitis...
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Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma

Subramani , Lopez-Valdez R, Salcido A, Boopalan T, Arumugam A, Nandy S, Lakshmanaswamy R

Pancreatic cancer is the only major cancer with very low survival rates (1%). It is the fourth leading cause of cancer-related death. Hyperactivated growth hormone receptor (GHR) levels have been...
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miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6

Li F, Li XJ, Qiao L, Shi F, Liu W, Li Y, Dang YP, Gu WJ, Wang XG, Liu W

Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression...
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