- A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met
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Chaudhary , Cho MG, Nguyen TT, Park KS, Kwon MH, Lee JH
- KMID: 2155384
- Exp Mol Med.
- 2014 Oct;46(10):e119.
- doi: 10.1038/emm.2014.67
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of some cells irrespective of ligand stimulation, but the responsible nuclear localization signal (NLS) has not... -
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- miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6
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Li F, Li XJ, Qiao L, Shi F, Liu W, Li Y, Dang YP, Gu WJ, Wang XG, Liu W
- KMID: 2155381
- Exp Mol Med.
- 2014 Oct;46(10):e116.
- doi: 10.1038/emm.2014.63
Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression... -
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- Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma
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Subramani , Lopez-Valdez R, Salcido A, Boopalan T, Arumugam A, Nandy S, Lakshmanaswamy R
- KMID: 2155382
- Exp Mol Med.
- 2014 Oct;46(10):e117.
- doi: 10.1038/emm.2014.61
Pancreatic cancer is the only major cancer with very low survival rates (1%). It is the fourth leading cause of cancer-related death. Hyperactivated growth hormone receptor (GHR) levels have been... -
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- Chronic stress enhances progression of periodontitis via alpha1-adrenergic signaling: a potential target for periodontal disease therapy
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Lu H, Xu M, Wang F, Liu S, Gu J, Lin S
- KMID: 2155383
- Exp Mol Med.
- 2014 Oct;46(10):e118.
- doi: 10.1038/emm.2014.65
This study assessed the roles of chronic stress (CS) in the stimulation of the sympathetic nervous system and explored the underlying mechanisms of periodontitis. Using an animal model of periodontitis... -
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