- CD36, a scavenger receptor implicated in atherosclerosis
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Park YM
- KMID: 2155364
- Exp Mol Med.
- 2014 Jun;46(6):e99.
- doi: 10.1038/emm.2014.38
CD36 is a membrane glycoprotein that is present on various types of cells, including monocytes, macrophages, microvascular endothelial cells, adipocytes and platelets. Macrophage CD36 participates in atherosclerotic arterial lesion formation... -
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- Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
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Kimple ME, Neuman JC, Linnemann , Casey PJ
- KMID: 2155367
- Exp Mol Med.
- 2014 Jun;46(6):e102.
- doi: 10.1038/emm.2014.40
The worldwide prevalence of obesity is steadily increasing, nearly doubling between 1980 and 2008. Obesity is often associated with insulin resistance, a major risk factor for type 2 diabetes mellitus... -
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- CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women
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Wang L, Lu X, Wang D, Qu W, Li W, Xu X, Huang Q, Han X, Lv J
- KMID: 2155368
- Exp Mol Med.
- 2014 Jun;46(6):e103.
- doi: 10.1038/emm.2014.31
An aromatase encoded by the CYP19 gene catalyzes the final step in the biosynthesis of estrogens, which is related to endometriosis development. To assess the association of CYP19 gene polymorphisms... -
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- Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells
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Han SM, Han SH, Coh YR, Jang G, Chan Ra J, Kang SK, Lee HW, Youn HY
- KMID: 2155366
- Exp Mol Med.
- 2014 Jun;46(6):e101.
- doi: 10.1038/emm.2014.28
Mesenchymal stem cells (MSCs) are attractive candidates for clinical repair or regeneration of damaged tissues. Oct4 and Sox2, which are essential transcription factors for pluripotency and self-renewal, are naturally expressed... -
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- Benzylideneacetophenone derivatives attenuate IFN-gamma-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition
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Lee SH, Lim SY, Choi JH, Jung JC, Oh S, Kook KH, Choi YH
- KMID: 2155365
- Exp Mol Med.
- 2014 Jun;46(6):e100.
- doi: 10.1038/emm.2014.26
The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized... -
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