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MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis

Jia J, Feng X, Xu W, Yang S, Zhang Q, Liu X, Feng Y, Dai Z

MicroRNAs (miRNAs) have recently been recognized to have a role in human orthopedic disorders. The objective of our study was to explore the expression profile and biological function of miRNA-17-5p...
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APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions

Thakur S, Sarkar B, Cholia RP, Gautam N, Dhiman M, Mantha AK

Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved in the base excision repair (BER) pathway, which repairs oxidative base damage caused by endogenous and exogenous agents. APE1 acts as...
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CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation

Cho B, Cho HM, Kim HJ, Jeong J, Park SK, Hwang EM, Park JY, Kim WR, Kim H, Sun W

Mitochondrial functions are essential for the survival and function of neurons. Recently, it has been demonstrated that mitochondrial functions are highly associated with mitochondrial morphology, which is dynamically changed by...
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Kruppel-like factor 4 mediates lysophosphatidic acid-stimulated migration and proliferation of PC3M prostate cancer cells

Shin SH, Kwon YW, Heo SC, Jeong GO, Kim BR, Seo EJ, Kim JH

Prostate cancer is the most frequently diagnosed malignancy and the second leading cause of cancer mortality among men in the United States. Accumulating evidence suggests that lysophosphatidic acid (LPA) serves...
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