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Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice

Hong S, Hwang J, Kim JY, Shin KS, Kang SJ

Epidemiological studies have suggested an association between pesticide exposure and Parkinson's disease. In this study, we examined the neurotoxicity of an organochlorine pesticide, heptachlor, in vitro and in vivo. In...
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MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes

Zhang Y, Jia J, Yang S, Liu X, Ye S, Tian H

Osteoarthritis is a common cause of functional deterioration in older adults and is an immense burden on the aging population. Altered chondrogenesis is the most important pathophysiological process involved in...
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Recent advance in brown adipose physiology and its therapeutic potential

Lee YH, Jung YS, Choi D

Brown adipose tissue (BAT) is a specialized thermoregulatory organ that has a critical role in the regulation of energy metabolism. Specifically, energy expenditure can be enhanced by the activation of...
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Knockdown of 14-3-3zeta enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells

Lee YK, Hur W, Lee SW, Hong SW, Kim SW, Choi JE, Yoon SK

14-3-3zeta is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3zeta decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study,...
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Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells

Lee SJ, Hwang SO, Noh EJ, Kim DU, Nam M, Kim JH, Nam JH, Hoe KL

Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study,...
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Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease

Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS

The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the...
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