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Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice

Kim JK, Lee KS, Lee DK, Lee SY, Chang HY, Choi J, Lee JI

Nonalcoholic steatohepatitis (NASH) can progress into liver cirrhosis; however, no definite treatment is available. Omega-3 polyunsaturated fatty acid (omega-3) has been reported to alleviate experimental NASH, although its beneficial effect...
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Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid

Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y

Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is...
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Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells

Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K

Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have...
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Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

Hwang WC, Kim MK, Song JH, Choi KY, Min DS

Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase...
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