- beta1-integrin-dependent migration of microglia in response to neuron-released alpha-synuclein
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Kim C, Cho ED, Kim HK, You S, Lee HJ, Hwang D, Lee SJ
- KMID: 2155356
- Exp Mol Med.
- 2014 Apr;46(4):e91.
- doi: 10.1038/emm.2014.6
Chronic neuroinflammation is an integral pathological feature of major neurodegenerative diseases. The recruitment of microglia to affected brain regions and the activation of these cells are the major events leading... -
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- Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes
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Tsukamoto , Takeuchi M, Kawaguchi , Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C
- KMID: 2155354
- Exp Mol Med.
- 2014 Apr;46(4):e89.
- doi: 10.1038/emm.2013.161
LR11, also known as SorLA or SORL1, is a type-I membrane protein from which a large extracellular part, soluble LR11 (sLR11), is released by proteolytic shedding on cleavage with a... -
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- Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice
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Kim SW, Hur W, Li TZ, Lee YK, Choi JE, Hong SW, Lyoo KS, You CR, Jung ES, Jung CK, Park T, Um SJ, Yoon SK
- KMID: 2155357
- Exp Mol Med.
- 2014 Apr;46(4):e92.
- doi: 10.1038/emm.2014.10
Nonalcoholic steatohepatitis (NASH) is characterized by hepatocyte injury and inflammatory cell infiltration, which has been linked to peripheral insulin resistance and increased levels of triglycerides in the liver. The purposes... -
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- Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1
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Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CW
- KMID: 2155355
- Exp Mol Med.
- 2014 Apr;46(4):e90.
- doi: 10.1038/emm.2014.1
Syntenin is a PDZ domain-containing adaptor protein that has been recently shown to regulate migration and invasion in several tumors. Small cell lung cancer (SCLC) is notorious for its invasiveness... -
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