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Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state

Park IH, Kim KH, Choi HK, Shim JS, Whang SY, June Hahn , Kwon OJ, Oh IH

  • KMID: 2154263
  • Exp Mol Med.
  • 2013 Sep;45(9):e44.
With the increasing use of culture-expanded mesenchymal stromal cells (MSCs) for cell therapies, factors that regulate the cellular characteristics of MSCs have been of major interest. Oxygen concentration has been...
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Application of bispecific antibody against antigen and hapten for immunodetection and immunopurification

Kim H, Park S, Lee HK, Chung J

  • KMID: 2154262
  • Exp Mol Med.
  • 2013 Sep;45(9):e43.
We present a bispecific antibody that recognizes an antigen and a hapten and can be applied to various biological assays, including immunoblotting and immunoprecipitation. In immunoblot analysis of serum, an...
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U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis

Benz F, Roderburg , Vargas Cardenas D, Vucur M, Gautheron , Koch A, Zimmermann H, Janssen J, Nieuwenhuijsen L, Luedde M, Frey N, Tacke F, Trautwein , Luedde T

  • KMID: 2154261
  • Exp Mol Med.
  • 2013 Sep;45(9):e42.
MicroRNA (miRNA) levels in serum have recently emerged as potential novel biomarkers for various diseases. miRNAs are routinely measured by standard quantitative real-time PCR (qPCR); however, the high sensitivity of...
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MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma

Zhu H, Luo H, Zuo X

  • KMID: 2154260
  • Exp Mol Med.
  • 2013 Sep;45(9):e41.
miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic...
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The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis

Kim SD, Kwon S, Lee SK, Kook M, Lee HY, Song KD, Lee HK, Baek SH, Park CB, Bae YS

  • KMID: 2154259
  • Exp Mol Med.
  • 2013 Sep;45(9):e40.
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body...
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Brain site-specific proteome changes in aging-related dementia

Manavalan , Mishra M, Feng L, Sze SK, Akatsu H, Heese K

  • KMID: 2154258
  • Exp Mol Med.
  • 2013 Sep;45(9):e39.
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer's disease (AD)). Our study...
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