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Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells

Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Lee SR, Ko TH, Youm JB, Kim N, Ko KS, Rhee BD, Han J

  • KMID: 2154269
  • Exp Mol Med.
  • 2013 Oct;45(10):e50.
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a...
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Targeted resequencing of candidate genes reveals novel variants associated with severe Behcet's uveitis

Kim SJ, Lee S, Park C, Seo JS, Kim JI, Yu HG

  • KMID: 2154268
  • Exp Mol Med.
  • 2013 Oct;45(10):e49.
Behcet's disease (BD) is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent uveitis, oral and genital ulcers and skin lesions. To identify some pathogenic variants associated with...
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Discriminant analysis of prion sequences for prediction of susceptibility

Lee JH, Bae SE, Jung S, Ahn I, Son HS

  • KMID: 2154267
  • Exp Mol Med.
  • 2013 Oct;45(10):e48.
Prion diseases, including ovine scrapie, bovine spongiform encephalopathy (BSE), human kuru and Creutzfeldt-Jakob disease (CJD), originate from a conformational change of the normal cellular prion protein (PrPC) into abnormal protease-resistant...
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Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells

Choi BH, Chakraborty G, Baek K, Yoon HS

  • KMID: 2154266
  • Exp Mol Med.
  • 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38...
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In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis

Moon SJ, Park JS, Heo YJ, Kang CM, Kim EK, Lim MA, Ryu JG, Park SJ, Park KS, Sung YC, Park SH, Kim HY, Min JK, Cho ML

  • KMID: 2154265
  • Exp Mol Med.
  • 2013 Oct;45(10):e46.
Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in the pathogenesis of autoimmune diseases and has a pivotal role as both...
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Cancer cell metabolism: implications for therapeutic targets

Jang M, Kim SS, Lee J

  • KMID: 2154264
  • Exp Mol Med.
  • 2013 Oct;45(10):e45.
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can...
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