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B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells

Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD

  • KMID: 2154244
  • Exp Mol Med.
  • 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a...
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Retraction: Protective effects of transduced Tat-DJ-1 protein against oxidative stress and ischemic brain injury

Jeong HJ, Kim DW, Kim MJ, Woo SJ, Kim HR, Kim SM, Jo HS, Hwang HS, Kim DS, Cho SW, Won MH, Han KH, Park J, Eum WS, Choi SY

  • KMID: 2154243
  • Exp Mol Med.
  • 2013 May;45(5):e24.
No abstract available.
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Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice

Oh YB, Ahn M, Lee SM, Koh HW, Lee SH, Kim SH, Park BH

  • KMID: 2154242
  • Exp Mol Med.
  • 2013 May;45(5):e23.
Recent studies have documented that Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) pathway can modulate the apoptotic program in a myocardial ischemia/reperfusion (I/R) model. To date, however, limited...
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Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein

Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ

  • KMID: 2154241
  • Exp Mol Med.
  • 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in...
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Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription

Sweatt JD

  • KMID: 2154240
  • Exp Mol Med.
  • 2013 May;45(5):e21.
TCF4 (transcription factor 4; E2-2, ITF2) is a transcription factor that when haplo-insufficient causes Pitt-Hopkins Syndrome (PTHS), an autism-spectrum disorder that is associated with pervasive developmental delay and severe intellectual...
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