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Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells

Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS

  • KMID: 2154257
  • Exp Mol Med.
  • 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been...
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Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet beta cells

Kalwat MA, Thurmond D

  • KMID: 2154256
  • Exp Mol Med.
  • 2013 Aug;45(8):e37.
The maintenance of whole-body glucose homeostasis is critical for survival, and is controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet beta cells secrete insulin in response...
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LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W

  • KMID: 2154255
  • Exp Mol Med.
  • 2013 Aug;45(8):e36.
Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts...
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TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts

Park ES, Kim J, Ha TU, Choi JS, Hong KS, Rho J

  • KMID: 2154254
  • Exp Mol Med.
  • 2013 Aug;45(8):e35.
Apoptosis has an important role in maintaining tissue homeostasis in cellular stress responses such as inflammation, endoplasmic reticulum stress, and oxidative stress. T-cell death-associated gene 51 (TDAG51) is a member...
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Characterizing affinity epitopes between prion protein and beta-amyloid using an epitope mapping immunoassay

Kang M, Kim SY, An SS, Ju YR

  • KMID: 2154253
  • Exp Mol Med.
  • 2013 Aug;45(8):e34.
Cellular prion protein, a membrane protein, is expressed in all mammals. Prion protein is also found in human blood as an anchorless protein, and this protein form is one of...
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