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MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis

Lee DG, Woo JW, Kwok SK, Cho ML, Park SH

  • KMID: 2154239
  • Exp Mol Med.
  • 2013 Apr;45(4):e20.
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies...
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The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis

Kim SK, Cho SM, Kim H, Seok H, Kim SO, Kwon TK, Chang JS

  • KMID: 2154238
  • Exp Mol Med.
  • 2013 Apr;45(4):e19.
New colchicine analogs have been synthesized with the aim of developing stronger potential anticancer activities. Among the analogs, CT20126 has been previously reported to show immunosuppressive activities. Here, we report...
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ISG15: leading a double life as a secreted molecule

Bogunovic , Boisson-Dupuis S, Casanova J

  • KMID: 2154237
  • Exp Mol Med.
  • 2013 Apr;45(4):e18.
ISG15 is a well-known intracellular ubiquitin-like molecule involved in ISGylation. However, a recent study has revived the notion first put forward two decades ago that ISG15 is also a secreted...
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Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways

Shin SH, Lee YM

  • KMID: 2154236
  • Exp Mol Med.
  • 2013 Apr;45(4):e17.
The anti-melanogenesis effect of glyceollins was examined by melanin synthesis, tyrosinase activity assay in zebrafish embryos and in B16F10 melanoma cells. When developing zebrafish embryos were treated with glyceollins, pigmentation...
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