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Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes

Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, Kim EH, Yoo HJ, Lee CH, Park IS, Lee KU, Koh EH

  • KMID: 1389736
  • Exp Mol Med.
  • 2012 Sep;44(9):562-570.
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER stress response, resulting...
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Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays

Park S, Hwang D, Chung J

  • KMID: 1389735
  • Exp Mol Med.
  • 2012 Sep;44(9):554-561.
Aptamers are synthetic, relatively short (e.g., 20-80 bases) RNA or ssDNA oligonucleotides that can bind targets with high affinity and specificity, similar to antibodies, because they can fold into unique,...
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Inhibition of mouse brown adipocyte differentiation by second-generation antipsychotics

Oh JE, Cho YM, Kwak SN, Kim JH, Lee KW, Jung H, Jeong SW, Kwon OJ

  • KMID: 1389734
  • Exp Mol Med.
  • 2012 Sep;44(9):545-553.
Brown adipose tissue is specialized to burn lipids for thermogenesis and energy expenditure. Second-generation antipsychotics (SGA) are the most commonly used drugs for schizophrenia with several advantages over first-line drugs,...
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Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner

Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA

  • KMID: 1389733
  • Exp Mol Med.
  • 2012 Sep;44(9):536-544.
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a...
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Over-expression of extracellular superoxide dismutase in mouse synovial tissue attenuates the inflammatory arthritis

Yu DH, Yi JK, Yuh HS, Park SJ, Kim HJ, Bae KB, Ji YR, Kim NR, Park SJ, Kim DH, Kim SH, Kim MO, Lee JW, Ryoo ZY

  • KMID: 1389732
  • Exp Mol Med.
  • 2012 Sep;44(9):529-535.
Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular-superoxide dismutase...
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Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way

Kim M, Song K, Jin EJ, Sonn J

  • KMID: 1389731
  • Exp Mol Med.
  • 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation...
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