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A priming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection

Chamniansawat S, Chongthammakun S

  • KMID: 1383803
  • Exp Mol Med.
  • 2012 Jun;44(6):403-411.
The localization of estrogen (E2) has been clearly shown in hippocampus, called local hippocampal E2. It enhanced neuronal synaptic plasticity and protected neuron form cerebral ischemia, similar to those effects...
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Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women

Kim HY, Hwang JY, Han BG, Lee JY, Park EK, Kim BJ, Lee SH, Kim GS, Kim SY, Koh JM

  • KMID: 1383802
  • Exp Mol Med.
  • 2012 Jun;44(6):394-402.
Adiponectin may affect bone through interactions with two known receptors, adiponectin receptors (ADIPOR) 1 and 2. We examined the association between polymorphisms of ADIPOR1 and ADIPOR2 and bone mineral density...
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Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression

Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH

  • KMID: 1383801
  • Exp Mol Med.
  • 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism...
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12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity

Lee JW, Ryu HC, Ng YC, Kim C, Wei JD, Sabaratnam V, Kim JH

  • KMID: 1383800
  • Exp Mol Med.
  • 2012 Jun;44(6):378-386.
12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. Despite the high level of 12-HHT present in tissues and bodily fluids,...
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A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells

Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY

  • KMID: 1383799
  • Exp Mol Med.
  • 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound...
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Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of alpha1c proteins

Park SA, Kim TG, Han MK, Ha KC, Kim SZ, Kwak YG

  • KMID: 1383798
  • Exp Mol Med.
  • 2012 Jun;44(6):363-368.
Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides. However, the effects of DNP on the cardiac...
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