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Overexpression of bone morphogenetic protein 4 in STO fibroblast feeder cells represses the proliferation of mouse embryonic stem cells in vitro

Kim GH, Lee GR, Choi HI, Park NH, Chung HT, Han IS

  • KMID: 1397450
  • Exp Mol Med.
  • 2012 Jul;44(7):457-463.
Embryonic stem cells (ESCs) can be propagated in vitro on feeder layers of mouse STO fibroblast cells. The STO cells secrete several cytokines that are essential for ESCs to maintain...
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Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model

Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH

  • KMID: 1397449
  • Exp Mol Med.
  • 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate...
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Synergy between adiponectin and interleukin-1beta on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes

Lee YA, Choi HM, Lee SH, Yang HI, Yoo MC, Hong SJ, Kim KS

  • KMID: 1397448
  • Exp Mol Med.
  • 2012 Jul;44(7):440-447.
To determine whether adiponectin may have synergistic effects in combination with the proinflammatory cytokine interleukin (IL)-1beta regarding the production of proinflammatory mediators during arthritic joint inflammation, synovial cells from rheumatoid...
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Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis

Kim WK, Kim JC, Park HJ, Sul OJ, Lee MH, Kim JS, Choi HS

  • KMID: 1397447
  • Exp Mol Med.
  • 2012 Jul;44(7):432-439.
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by...
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Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation

Jhun JY, Yoon BY, Park MK, Oh HJ, Byun JK, Lee SY, Min JK, Park SH, Kim HY, Cho ML

  • KMID: 1397446
  • Exp Mol Med.
  • 2012 Jul;44(7):424-431.
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-alpha. Rheumatoid arthritis...
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Homophilic interaction of the L1 family of cell adhesion molecules

Wei CH, Ryu SE

  • KMID: 1397445
  • Exp Mol Med.
  • 2012 Jul;44(7):413-423.
Homophilic interaction of the L1 family of cell adhesion molecules plays a pivotal role in regulating neurite outgrowth and neural cell networking in vivo. Functional defects in L1 family members...
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