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Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells both in vitro and in vivo

Kim J, Kim OS, Kim CS, Sohn E, Jo K, Kim JS

The formation of advanced glycation end products (AGEs) has been considered to be a potential causative factor of injury to lens epithelial cells (LECs). Damage of LECs is believed to...
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Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells

Kim KH, Kim YM, Lee MJ, Ko HC, Kim MB, Kim JH

Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle-like cells expressing alpha-smooth muscle actin (alpha-SMA) via transforming growth factor-beta1/Smad2- and RhoA/Rho kinase-dependent mechanisms. 3-Hydroxy-3-methylglutaryl-coenzyme...
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The presence of high level soluble herpes virus entry mediator in sera of gastric cancer patients

Heo SK, Ju SA, Kim GY, Park SM, Back SH, Park NH, Min YJ, An WG, Nguyen TH, Kim SM, Kim BS

The development of gastric cancer (GC) is closely related to chronic inflammation caused by Helicobacter pylori infection, and herpes virus entry mediator (HVEM) is a receptor expressed on the surface...
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Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation

Ha YJ, Jeong JH, Park Y, Lee JR

Previously, we demonstrated that the p190 Rho guanine nucleotide exchange factor (p190RhoGEF) was induced following CD40 stimulation of B cells. In this study, we examined whether p190RhoGEF and a downstream...
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Identification of novel peptides that stimulate human neutrophils

Bae GH, Lee HY, Jung YS, Shim JW, Kim SD, Baek SH, Kwon JY, Park JS, Bae YS

Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is a very important issue. In this study, we identified three novel...
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Genetic association of the EGR2 gene with bipolar disorder in Korea

Kim SH, Song JY, Joo EJ, Lee KY, Shin SY, Lee YH, Ahn YM, Kim YS

The early growth response gene 2 (EGR2) is located at chromosome 10q21, one of the susceptibility loci in bipolar disorder (BD). EGR2 is involved in cognitive function, myelination, and signal...
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Autophagy and cancer

Choi KS

Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic integrity by degrading aged or malfunctioning organelles and damaged or misfolded proteins. However, autophagy also plays a complicated...
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Autophagy and bacterial infectious diseases

Yuk JM, Yoshimori , Jo EK

Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested...
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Neuronal autophagy and neurodegenerative diseases

Son JH, Shim JH, Kim KH, Ha JY, Han JY

Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. The integrity of postmitotic neurons is heavily dependent on high basal...
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Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells

Quan W, Lim YM, Lee MS

Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Autophagy plays a crucial role in cellular homeostasis through degradation and recycling of organelles...
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Molecules and their functions in autophagy

Pyo JO, Nah J, Jung YK

Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved...
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Why is autophagy important in human diseases?

Jing K, Lim K

The process of macroautophagy (referred to hereafter as autophagy), is generally characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past decades, studies of autophagy have...
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