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Cinnamyl alcohol attenuates vasoconstriction by activation of K+ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase

Kang YH, Yang IJ, Morgan KG, Shin HM

  • KMID: 1402319
  • Exp Mol Med.
  • 2012 Dec;44(12):749-755.
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate the vasodilatory effect and the mechanism of...
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Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function

Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL

  • KMID: 1402318
  • Exp Mol Med.
  • 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the...
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KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model

Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT

  • KMID: 1402317
  • Exp Mol Med.
  • 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive...
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Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells

He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J

  • KMID: 1402316
  • Exp Mol Med.
  • 2012 Dec;44(12):723-732.
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors....
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Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation

Kang SS, Shin SH, Auh CK, Chun J

  • KMID: 1402315
  • Exp Mol Med.
  • 2012 Dec;44(12):707-722.
The transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is expressed in a broad range of tissues where it participates in the generation...
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