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Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells

Lee Y, Choi J, Ha KH, Jue DM

  • KMID: 1387362
  • Exp Mol Med.
  • 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The...
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Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture

Choi MR, In YH, Park J, Park T, Jung KH, Chai JC, Chung MK, Lee YS, Chai YG

  • KMID: 1387361
  • Exp Mol Med.
  • 2012 Aug;44(8):503-512.
Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic...
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Analysis of differential plaque depositions in the brains of Tg2576 and Tg-APPswe/PS1dE9 transgenic mouse models of Alzheimer disease

Kim TK, Lee JE, Park SK, Lee KW, Seo JS, Im JY, Kim ST, Lee JY, Kim YH, Lee JK, Han PL

  • KMID: 1387360
  • Exp Mol Med.
  • 2012 Aug;44(8):492-502.
Adequate assessment of plaque deposition levels in the brain of mouse models of Alzheimer disease (AD) is required in many core issues of studies on AD, including studies on the...
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Synergistic induction of cancer cell migration regulated by Gbetagamma and phosphatidylinositol 3-kinase

Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Woo DH, Lee HS, Ha HK, Bae SS

  • KMID: 1387359
  • Exp Mol Med.
  • 2012 Aug;44(8):483-491.
Phosphatidylinositol 3-kinase (PI3K) is essential for both G protein-coupled receptor (GPCR)- and receptor tyrosine kinase (RTK)-mediated cancer cell migration. Here, we have shown that maximum migration is achieved by full...
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A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-beta1-induced MMP-1 and MMP-9 expression in breast cancer cells

Kim S, Han J, Shin I, Kil WH, Lee JE, Nam SJ

  • KMID: 1387358
  • Exp Mol Med.
  • 2012 Aug;44(8):473-482.
Overexpression of HER2 correlates with more aggressive tumors and increased resistance to cancer chemotherapy. However, a functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on tumor metastasis has not...
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B cell-associated immune profiles in patients with end-stage renal disease (ESRD)

Kim KW, Chung BH, Jeon EJ, Kim BM, Choi BS, Park CW, Kim YS, Cho SG, Cho ML, Yang CW

  • KMID: 1387357
  • Exp Mol Med.
  • 2012 Aug;44(8):465-472.
Most of the previous studies on immune dysregulation in end-stage renal disease (ESRD) have focused on T cell immunity. We investigated B cell subpopulations in ESRD patients and the effect...
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