- Frontier of Epilepsy Research - mTOR signaling pathway
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Cho CH
- KMID: 1009965
- Exp Mol Med.
- 2011 May;43(5):231-274.
- doi: 10.3858/emm.2011.43.5.032
Studies of epilepsy have mainly focused on the membrane proteins that control neuronal excitability. Recently, attention has been shifting to intracellular proteins and their interactions, signaling cascades and feedback regulation... -
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- miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1
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Arora H, Qureshi R, Jin S, Park AK, Park WY
- KMID: 1009969
- Exp Mol Med.
- 2011 May;43(5):298-304.
- doi: 10.3858/emm.2011.43.5.031
The activation of nuclear factor-kappa B1 (NFkappaB1) in cancer cells may confer resistance to ionizing radiation (IR). To enhance the therapeutic efficiency of IR in lung cancer, we screened for... -
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- PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase
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Lee Y, Kim SJ, Min HJ, Jo JY, Park EH, Koh SS
- KMID: 1009968
- Exp Mol Med.
- 2011 May;43(5):291-297.
- doi: 10.3858/emm.2011.43.5.030
Pancreatic cancer is a notorious disease with a poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of... -
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- Alveolar macrophages modulate allergic inflammation in a murine model of asthma
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Bang BR, Chun E, Shim EJ, Lee HS, Lee SY, Cho SH, Min KU, Kim YY, Park HW
- KMID: 1009966
- Exp Mol Med.
- 2011 May;43(5):275-280.
- doi: 10.3858/emm.2011.43.5.028
The role of alveolar macrophages (AMs) in the pathogenesis of asthma is still unknown. The aim of the present study was to investigate the effects of AM in the murine... -
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- Introduction of the CIITA gene into tumor cells produces exosomes with enhanced anti-tumor effects
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Lee YS, Kim SH, Cho JA, Kim CW
- KMID: 1009967
- Exp Mol Med.
- 2011 May;43(5):281-290.
- doi: 10.3858/emm.2011.43.5.029
Exosomes are small membrane vesicles secreted from various types of cells. Tumor-derived exosomes contain MHC class I molecules and tumor-specific antigens, receiving attention as a potential cancer vaccine. For induction... -
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- Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma
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Jang JW, Park ST, Kwon JH, You CR, Choi JY, Jung CK, Bae SH, Yoon SK
- KMID: 1009970
- Exp Mol Med.
- 2011 May;43(5):305-312.
- doi: 10.3858/emm.2011.43.5.033
Although continuous low-dose (metronomic [MET]) therapy exerts anti-cancer efficacy in various cancer models, the effect of long-term MET therapy for hepatocellular carcinoma (HCC) remains unknown. This study assessed the long-term... -
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- Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling
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Kim BH, Min YS, Choi JS, Baeg GH, Kim Y, Shin JW, Kim TY, Ye SK
- KMID: 1009971
- Exp Mol Med.
- 2011 May;43(5):313-321.
- doi: 10.3858/emm.2011.43.5.035
Persistently activated JAK/STAT3 signaling pathway plays a pivotal role in various human cancers including major carcinomas and hematologic tumors, and is implicated in cancer cell survival and proliferation. Therefore, inhibition... -
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