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Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

Shen M, Zhang L, Lee KM, Vermeulen , Hosgood HD, Li G, Yin S, Rothman N, Chanock S, Smith MT, Lan Q

Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity...
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Effects of combined mechanical stimulation on the proliferation and differentiation of pre-osteoblasts

Kang KS, Lee SJ, Lee H, Moon W, Cho DW

We observed how combined mechanical stimuli affect the proliferation and differentiation of pre-osteoblasts. For this research, a bioreactor system was developed that can simultaneously stimulate cells with cyclic strain and...
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Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues

Shen Y, Li Y, Ye F, Wang F, Wan X, Lu W, Xie X

Quantitative real-time RT-PCR (RT-qPCR) is being widely used in microRNA expression research. However, few reports detailed a robust identification and validation strategy for suitable reference genes for normalisation in microRNA...
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Regulation of B cell activating factor (BAFF) receptor expression by NF-kappaB signaling in rheumatoid arthritis B cells

Woo YJ, Yoon BY, Jhun JY, Oh HJ, Min S, Cho ML, Park SH, Kim HY, Min JK

B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). High levels of B cell activating factor (BAFF) are detected in autoimmune diseases. BAFF and BAFF receptor...
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Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats

Paik YH, Yoon YJ, Lee HC, Jung MK, Kang SH, Chung SI, Kim JK, Cho JY, Lee KS, Han KH

Magnesium lithospermate B (MLB) is one of the major active components of Salvia miltiorrhizae. The anti-oxidative effects of Salvia miltiorrhizae have been previously reported. The aim of this study was...
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Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms

Cho H, Park SH, Lee S, Kang M, Hasty KA, Kim SJ

Larger animal models, such as porcine, have been validated as appropriate models of the human disc with respect to biomechanics and biochemistry. They are advantageous for research as the models...
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Phenylpropanoids in radioregulation: double edged sword

Kim W, Seong KM, Youn B

Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals...
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