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Endothelial progenitor cell transplantation decreases lymphangiogenesis and adverse myocardial remodeling in a mouse model of acute myocardial infarction

Park JH, Yoon JY, Ko SM, Jin SA, Kim JH, Cho CH, Kim JM, Lee JH, Choi SW, Seong IW, Jeong JO

Cardiac lymphatic system in the remodeling after acute myocardial infarction (AMI) has been overlooked. We wanted to investigate the role of bone marrow-derived endothelial progenitor cells (EPCs) and their contribution...
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5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion

Choi JH, Park JG, Jeon HJ, Kim MS, Lee MR, Lee MN, Sonn S, Kim JH, Lee MH, Choi MS, Park YB, Kwon OS, Jeong TS, Lee WS, Shim HB, Shin DH, Oh GT

A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of...
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JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Cho IH, Lee KW, Ha HY, Han PL

We previously reported that mice lacking JSAP1 (jsap1-/-) were lethal and the brain of jsap1-/- at E18.5 exhibited multiple types of developmental defects, which included impaired axon projection of the...
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TiO2 nanotube stimulate chondrogenic differentiation of limb mesenchymal cells by modulating focal activity

Kim D, Choi B, Song J, Kim S, Oh S, Jin EH, Kang SS, Jin EJ

Vertically aligned, laterally spaced nanoscale titanium nanotubes were grown on a titanium surface by anodization, and the growth of chondroprogenitors on the resulting surfaces was investigated. Surfaces bearing nanotubes of...
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Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts

Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH

Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue...
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Ischemic postconditioning protects cardiomyocytes against ischemia/reperfusion injury by inducing MIP2

Zhu HL, Wei X, Qu SL, Zhang C, Zuo XX, Feng YS, Luo Q, Chen GW, Liu MD, Jiang L, Xiao XZ, Wang KK

Cardiomyocytes can resist ischemia/reperfusion (I/R) injury through ischemic postconditioning (IPoC) which is repetitive ischemia induced during the onset of reperfusion. Myocardial ischemic preconditioning up-regulated protein 2 (MIP2) is a member...
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