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Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia

Lee HS, Kim CK

Alveolar type II cells are main target of hyperoxia-induced lung injury. The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the...
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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ

Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have...
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Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism

Seo JB, Choe SS, Jeong HW, Park SW, Shin HJ, Choi SM, Park JY, Choi EW, Kim JB, Seen DS, Jeong JY, Lee TG

Lysimachia foenum-graecum has been used as an oriental medicine with anti-inflammatory effect. The anti-obesity effect of L. foenum-graecum extract (LFE) was first discovered in our screening of natural product extract...
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Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice

Li Y, Sun M, Cheng H, Li S, Liu L, Qiao H, Hua S, Lu J

To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19...
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Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells

Wang MF, Liao YF, Hung YC, Lin CL, Hour TC, Lue KH, Hung HC, Liu GY

Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising chemopreventive agent. In this...
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Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration

Chung JH, Im EK, Jin T, Lee SM, Kim SH, Choi EY, Shin MJ, Lee KH, Jang Y

Gene transfer of basic fibroblast growth factor (bFGF) has been shown to induce significant endothelial migration and angiogenesis in ischemic disease models. Here, we investigate what factors are secreted from...
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Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-gamma

Lee BJ, Moon HG, Shin TS, Jeon SG, Lee EY, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK

Recent clinical evidence indicates that the non-eosinophilic subtype of severe asthma is characterized by fixed airway obstruction, which may be related to emphysema. Transgenic studies have demonstrated that high levels...
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