- A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
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Kim JW, Kim TD, Hong BS, Kim OY, Yoon WH, Chae CB, Gho YS
- KMID: 1104211
- Exp Mol Med.
- 2010 Jul;42(7):514-523.
- doi: 10.3858/emm.2010.42.7.052
Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for... -
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- IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation
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Chen F, Zhu HH, Zhou LF, Wu SS, Wang J, Chen Z
- KMID: 1104208
- Exp Mol Med.
- 2010 Jul;42(7):477-483.
- doi: 10.3858/emm.2010.42.7.049
The scaffold protein IQGAP1 shows elevated levels in several cancer types, but its expression in hepatocellular carcinoma is unknown. We found that 58% of human hepatocellular carcinoma tissue samples had... -
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- Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity
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Woo A, Min B, Ryoo S
- KMID: 1104212
- Exp Mol Med.
- 2010 Jul;42(7):524-532.
- doi: 10.3858/emm.2010.42.7.053
Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases... -
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- 2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes
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Yu SM, Kim HA, Kim SJ
- KMID: 1104210
- Exp Mol Med.
- 2010 Jul;42(7):503-513.
- doi: 10.3858/emm.2010.42.7.051
2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the... -
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- Integrative epigenomic and genomic analysis of malignant pheochromocytoma
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Sandgren J, Andersson , Rada-Iglesias A, Enroth S, Akerstrom , Dumanski J, Komorowski J, Westin G, Wadelius C
- KMID: 1104209
- Exp Mol Med.
- 2010 Jul;42(7):484-502.
- doi: 10.3858/emm.2010.42.7.050
Epigenomic and genomic changes affect gene expression and contribute to tumor development. The histone modifications trimethylated histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) are epigenetic regulators associated to... -
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