- Got target?: computational methods for microRNA target prediction and their extension
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Min H, Yoon S
- KMID: 983972
- Exp Mol Med.
- 2010 Apr;42(4):233-244.
- doi: 10.3858/emm.2010.42.4.032
MicroRNAs (miRNAs) are a class of small RNAs of 19-23 nucleotides that regulate gene expression through target mRNA degradation or translational gene silencing. The miRNAs are reported to be involved... -
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- Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance
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Dandona P, Ghanim H, Chaudhuri , Dhindsa S, Kim SS
- KMID: 983973
- Exp Mol Med.
- 2010 Apr;42(4):245-253.
- doi: 10.3858/emm.2010.42.4.033
With the global increase in the epidemic of obesity and type 2 diabetes with a concomitant increase in atherosclerotic disease, an investigation into the effects of various macronutrients and food... -
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- Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation
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Nam HJ, Park YY, Yoon G, Cho H, Lee JH
- KMID: 983975
- Exp Mol Med.
- 2010 Apr;42(4):270-279.
- doi: 10.3858/emm.2010.42.4.026
Wound healing requires re-epithelialization from the wound margin through keratinocyte proliferation and migration, and some growth factors are known to influence this process. In the present study, we found that... -
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- A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production
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Lee HY, Kim SD, Shim JW, Kim HJ, Yun J, Baek SH, Kim K, Bae YS
- KMID: 983978
- Exp Mol Med.
- 2010 Apr;42(4):302-309.
- doi: 10.3858/emm.2010.42.4.029
Serum amyloid A (SAA) induced CCL2 production via a pertussis toxin (PTX)-insensitive pathway in human umbilical vein endothelial cells (HUVECs). SAA induced the activation of three MAPKs (ERK, p38 MAPK,... -
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- PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro
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Lee HJ, Jeong CH, Cha JH, Kim KW
- KMID: 983977
- Exp Mol Med.
- 2010 Apr;42(4):294-301.
- doi: 10.3858/emm.2010.42.4.028
Under hypoxia, mouse embryonic stem cells (mESCs) lose their self-renewal activity and display an early differentiated morphology mediated by the hypoxia-inducible factor-1alpha (HIF-1alpha). Previous studies have demonstrated that PKC-delta is... -
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- Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts
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Kwon HJ, Rhim JH, Jang IS, Kim GE, Park SC, Yeo EJ
- KMID: 983974
- Exp Mol Med.
- 2010 Apr;42(4):254-269.
- doi: 10.3858/emm.2010.42.4.025
In addition to its well-known glycolytic activity, GAPDH displays multiple functions, such as nuclear RNA export, DNA replication and repair, and apoptotic cell death. This functional diversity depends on its intracellular... -
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- Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer
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Cho SY, Choi K, Jeon JH, Kim CW, Shin DM, Lee JB, Lee SE, Kim CS, Park JS, Jeong EM, Jang GY, Song KY, Kim IG
- KMID: 983979
- Exp Mol Med.
- 2010 Apr;42(4):310-318.
- doi: 10.3858/emm.2010.42.4.031
Transglutaminase 4 is a member of enzyme family that catalyzes calcium-dependent posttranslational modification of proteins. Although transglutaminase 4 has been shown to have prostate-restricted expression pattern, little is known about... -
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- Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1alpha from human mesenchymal stem cells
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Jeon ES, Heo SC, Lee IH, Choi YJ, Park JH, Choi KU, Park DY, Suh DS, Yoon MS, Kim JH
- KMID: 983976
- Exp Mol Med.
- 2010 Apr;42(4):280-293.
- doi: 10.3858/emm.2010.42.4.027
Lysophosphatidic acid (LPA) stimulates growth and invasion of ovarian cancer cells and tumor angiogenesis. Cancer-derived LPA induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) to alpha-smooth muscle actin... -
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