- Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein
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Hong KU, Kim HJ, Bae CD, Park J
- KMID: 1122284
- Exp Mol Med.
- 2009 Nov;41(11):832-840.
- doi: 10.3858/emm.2009.41.11.089
Tumor-associated microtubule-associated protein (TMAP), also known as cytoskeleton associated protein 2 (CKAP2), has been recently shown to be involved in the assembly and maintenance of mitotic spindle and also plays... -
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- The function of p27(KIP1) during tumor development
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Lee J, Kim SS
- KMID: 1122277
- Exp Mol Med.
- 2009 Nov;41(11):765-771.
- doi: 10.3858/emm.2009.41.11.102
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which... -
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- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
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Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY
- KMID: 1122283
- Exp Mol Med.
- 2009 Nov;41(11):824-831.
- doi: 10.3858/emm.2009.41.11.088
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE... -
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- Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans
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Park JW, Ji YI, Choi YH, Kang MY, Jung E, Cho SY, Cho HY, Kang BK, Joung YS, Kim DH, Park SC, Park J
- KMID: 1122278
- Exp Mol Med.
- 2009 Nov;41(11):772-781.
- doi: 10.3858/emm.2009.41.11.083
Long-lived people may have a unique genetic makeup that makes them more resistant than the general population to prevalent age-related diseases; however, not much is known about genes involved in... -
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- Analysis of genetic and non-genetic factors that affect the QTc interval in a Mongolian population: the GENDISCAN study
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Im SW, Lee MK, Lee HJ, Oh SI, Kim HL, Sung J, Cho SI, Seo JS, Kim JI
- KMID: 1122285
- Exp Mol Med.
- 2009 Nov;41(11):841-848.
- doi: 10.3858/emm.2009.41.11.090
The QTc interval is a complex quantitative trait and a strong prognostic indicator of cardiovascular mortality in general, healthy people. The aim of this study was to identify non-genetic factors... -
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- Effect of nicotinamide on early graft failure following intraportal islet transplantation
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Jung DY, Park JB, Joo SY, Joh JW, Kwon CH, Kwon GY, Kim SJ
- KMID: 1122279
- Exp Mol Med.
- 2009 Nov;41(11):782-792.
- doi: 10.3858/emm.2009.41.11.084
Intraportal islet transplantation (IPIT) may potentially cure Type 1 diabetes mellitus; however, graft failure in the early post-transplantation period presents a major obstacle. In this study, we tested the ability... -
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- The enabled homolog gene polymorphisms are associated with susceptibility and progression of childhood IgA nephropathy
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Hahn WH, Suh JS, Cho BS, Kim SD
- KMID: 1122280
- Exp Mol Med.
- 2009 Nov;41(11):793-801.
- doi: 10.3858/emm.2009.41.11.085
The enabled homolog gene (ENAH, hMena) is abundantly expressed in mesangial tissue, and might play an important role in inflammatory processes of IgA nephropathy (IgAN). The present study was conducted... -
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- Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy
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Yoon SJ, Yoon YW, Lee BK, Kwon HM, Hwang KC, Kim M, Chang W, Hong BK, Lee YH, Park SJ, Min PK, Rim SJ
- KMID: 1122281
- Exp Mol Med.
- 2009 Nov;41(11):802-811.
- doi: 10.3858/emm.2009.41.11.086
Advanced glycation endproducts (AGEs)-induced vascular smooth muscle cell (VSMCs) proliferation and formation of reactive oxygen species (ROS) are emerging as one of the important mechanisms of diabetic vasculopathy but little... -
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- Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with beta2-adrenergic agonist
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Kim SB, Han YW, Rahman MM, Kim SJ, Yoo DJ, Kang SH, Kim K, Eo SK
- KMID: 1122282
- Exp Mol Med.
- 2009 Nov;41(11):812-823.
- doi: 10.3858/emm.2009.41.11.087
Cholera toxin, which has been frequently used as mucosal adjuvant, leads to an irreversible activation of adenylyl cyclase, thereby accumulating cAMP in target cells. Here, it was assumed that beta2-adrenergic... -
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