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Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes

Jeon S, Kim NH, Koo BS, Kim JY, Lee AY

In this study, the essential oil from lotus flower extract, including petals and stamens, was assessed with regard to its effects on melanogenesis in human melanocytes. The lotus flower essential...
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Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro

Yang L, Zou XJ, Gao X, Chen H, Luo JL, Wang ZH, Liang QS, Yang GT

Cardiac fibrosis occurs after pathological stimuli to the cardiovascular system. One of the most important factors that contribute to cardiac fibrosis is angiotensin II (Ang II). Accumulating studies have suggested...
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Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro

Stogbauer , Weigert J, Neumeier M, Wanninger , Sporrer D, Weber M, Schaffler , Enrich C, Wood P, Grewal T, Aslanidis , Buechler C

Adiponectin stimulates cholesterol efflux in macrophages and low adiponectin may in part contribute to disturbed reverse cholesterol transport in type 2 diabetes. Monocytes express high levels of annexin A6 that...
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Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice

Park S, Kim HT, Yun S, Kim IS, Lee J, Lee IS, Park KI

Neural progenitor cells (NPs) have shown several promising benefits for the treatment of neurological disorders. To evaluate the therapeutic potential of human neural progenitor cells (hNPs) in amyotrophic lateral sclerosis...
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Transcriptional activation of insulin-like growth factor binding protein 6 by 17beta-estradiol in SaOS-2 cells

Zhao YY, Guo L, Zhao XJ, Liu H, Lei T, Ma DJ, Gao XY

Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation...
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Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin

Lee JE, Jang H, Cho EJ, Youn HD

Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage....
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Integrated analysis of copy number alteration and RNA expression profiles of cancer using a high-resolution whole-genome oligonucleotide array

Jung SH, Shin SH, Yim SH, Choi HS, Lee SH, Chung YJ

Recently, microarray-based comparative genomic hybridization (array-CGH) has emerged as a very efficient technology with higher resolution for the genome-wide identification of copy number alterations (CNA). Although CNAs are thought to...
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14-3-3epsilon protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cells

Lee EK, Lee YS, Lee H, Choi CY, Park SH

One of the 14-3-3 protein isoforms, 14-3-3epsilon, was previously shown to be increased during skin aging. We suggest here a possible role for the 14-3-3epsilon protein in skin aging by...
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