Skip Navigation
Skip to contents
Filter

ARTICLE TYPE

PUBLICATION DATE

16 results
Display

In vivo hepatitis B virus-neutralizing activity of an anti-HBsAg humanized antibody in chimpanzees

Kim SH, Oh HK, Ryu CJ, Park SY, Hong HJ

Previously, we constructed a humanized antibody (HuS10) that binds to the common a antigenic determinant on the S protein of HBV. In this study, we evaluated its HBV-neutralizing activity in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Anti-tumor immunostimulatory effect of heat-killed tumor cells

Yoon TJ, Kim JY, Kim H, Hong C, Lee H, Lee CK, Lee KH, Hong S, Park SH

As a part of our ongoing search for a safe and efficient anti-tumor vaccine, we attempted to determine whether the molecular nature of certain tumor antigens would influence immune responses...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases

Lee KB, Lee JS, Park JW, Huh TL, Lee YM

Proton beam is useful to target tumor tissue sparing normal cells by allowing precise dose only into tumor cells. However, the cellular and molecular mechanisms by which proton beam induces...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability

Lee W, Choi HI, Kim MJ, Park SY

The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Alterations of proliferative and differentiation potentials of human embryonic stem cells during long-term culture

Park YB, Kim YY, Oh SK, Chung SG, Ku SY, Kim SH, Choi YM, Moon SY

Human embryonic stem cells (hESCs) are considered to be able to stably maintain their characteristics in vitro for prolonged periods, but we had previously encountered changes in proliferative ability and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway

Park MH, Lee DH

Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Migration of human neural stem cells toward an intracranial glioma

Jeon JY, An JH, Kim SU, Park HG, Lee MA

Many in vivo and in vitro studies have demonstrated the targeted migration of neural stem cells (NSC) to infiltrating brain tumors, including malignant glioma, highlighting a potential therapeutic approach. However,...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Nur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradation

Kim BY, Kim H, Cho EJ, Youn HD

In this study, we investigated the role of Nur77, an orphan nuclear receptor, in HIF-alpha transcriptional activity. We found that Nur77 associates and stabilizes HIF-1alpha via indirect interaction. Nur77 was...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
RANKL stimulates proliferation, adhesion and IL-7 expression of thymic epithelial cells

Lee HW, Park HK, Na YJ, Kim CD, Lee JH, Kim BS, Kim JB, Lee CW, Moon JO, Yoon S

Abstract In many clinical situations which cause thymic involution and thereby result in immune deficiency, T cells are the most often affected, leading to a prolonged deficiency of T cells. Since...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB

Kyung TW, Lee JE, Shin HH, Choi HS

Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells

Lee YS, Lee EK, Han IO, Park SH

The inhibitory Smad6 and Smad7 are responsible for cross-talk between TGF-beta/bone morphogenic protein (BMP) signaling and other cellular signaling pathways, as well as negative feedback on their own signaling functions....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Characterization of a novel anti-human TNF-alpha murine monoclonal antibody with high binding affinity and neutralizing activity

Song MY, Park SK, Kim CS, Yoo TH, Kim B, Kim MS, Kim YS, Kwag WJ, Lee BK, Baek K

In order to develop an anti-human TNF-alpha mAb, mice were immunized with recombinant human TNF-alpha. A murine mAb, TSK114, which showed the highest binding activity for human TNF-alpha was selected...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Age-dependent dichotomous effect of superoxide dismutase Ala16Val polymorphism on oxidized LDL levels

Dedoussis , Kanoni S, Panagiotakos DB, Louizou E, Grigoriou , Chrysohoou C, Pitsavos C, Stefanadis C

We investigated the association between superoxide dismutase (SOD) Ala16Val polymorphism and the levels of oxidized LDL lipoprotein-C (ox-LDL-C) in two age-different Greek cohorts. Four hundred fifteen middle-aged (n=147 females: 43.2+/-13...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells

Seo DR, Kim SY, Kim KY, Lee HG, Moon JH, Lee JS, Lee SH, Kim SU, Lee YB

Previously we demonstrated that ATP released from LPS-activated microglia induced IL-10 expression in a process involving P2 receptors, in an autocrine fashion. Therefore, in the present study we sought to...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia

Moon JH, Kim SY, Lee HG, Kim SU, Lee YB

Recent studies have reported that the "cholinergic anti-inflammatory pathway" regulates peripheral inflammatory responses via alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) and that acetylcholine and nicotine regulate the expression of proinflammatory...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody

Jung DY, Kim EY, Joo SY, Park JB, Moon C, Kim SH, Sim EY, Joh JW, Kwon CH, Kwon GY, Kim SJ

Pancreatic islet transplantation can correct the abnormal glucose metabolism of Type 1 diabetes. Although immunosuppressants greatly reduce the acute rejection rate in transplant patients, the long-term side effects can be...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr