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Low-density lipoprotein protects Vibrio vulnificus-induced lethality through blocking lipopolysaccharide action

Park KH, Kim JS, Lee YR, Moon YJ, Hur H, Choi YH, Kim CH, Kim UH, Song EK, Yoo WH, Lee CS, Kim BS, Lee SH, Ryu PY, Han MK

  • KMID: 1090970
  • Exp Mol Med.
  • 2007 Oct;39(5):673-678.
Lipoprotein plays a role in the host defense against bacterial infection, and its serum level has been demonstrated to be an important prognosis factor of survival. We have previously demonstrated...
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Recombinant tetra-cell adhesion motifs supports adhesion, migration and proliferation of keratinocytes/fibroblasts, and promotes wound healing

Jung MY, Thapa N, Kim JE, Yang JD, Cho BC, Kim IS

  • KMID: 1090969
  • Exp Mol Med.
  • 2007 Oct;39(5):663-672.
An extracellular matrix protein plays an important role in skin wound healing. In the present study, we engineered a recombinant protein encompassing the 9th and 10th type III domains of...
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Cardiac side population cells exhibit endothelial differentiation potential

Yoon J, Choi SC, Park CY, Shim WJ, Lim DS

  • KMID: 1090968
  • Exp Mol Med.
  • 2007 Oct;39(5):653-662.
Recent studies have shown that side population (SP) cells, isolated from adult myocardium, represent a distinct cardiac progenitor cell population that exhibits functional cardiomyogenic differentiation. However, information on the intrinsic...
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Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma

Yu GR, Kim SH, Park SH, Cui XD, Xu DY, Yu HC, Cho BH, Yeom YI, Kim SS, Kim SB, Chu IS, Kim DG

  • KMID: 1090967
  • Exp Mol Med.
  • 2007 Oct;39(5):641-652.
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene...
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Change of connexin 37 in allergen-induced airway inflammation

Park SJ, Lee KS, Kim SR, Min KH, Lee KY, Choe YH, Park SY, Hong SH, Lee YC

  • KMID: 1090966
  • Exp Mol Med.
  • 2007 Oct;39(5):629-640.
Gap junction channels formed with connexins directly link to the cytoplasm of adjacent cells and have been implicated in intercellular signaling. Connexin 37 (Cx37) is expressed in the gas-exchange region...
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Immunocytochemical detection of HPV16 E7 in cervical smear

Jeon JH, Shin DM, Cho SY, Song KY, Park NH, Kang HS, Kim YD, Kim IG

  • KMID: 1090965
  • Exp Mol Med.
  • 2007 Oct;39(5):621-628.
Cervical cancer is characterized by a long period of preclinical dysplasia or carcinoma in situ progressing into invasive cancer. Although Papanicolaou (Pap) smear test has contributed significantly to the early...
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Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema

Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I

  • KMID: 1090964
  • Exp Mol Med.
  • 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to...
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Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration

Jeon S, Kim NH, Koo BS, Lee HJ, Lee AY

  • KMID: 1090963
  • Exp Mol Med.
  • 2007 Oct;39(5):603-613.
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A2(sPLA2) known as a component of bee venom (BV), stimulates...
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Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix

Lee EH, Allen PD

  • KMID: 1090962
  • Exp Mol Med.
  • 2007 Oct;39(5):594-602.
To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) homo-tetramerizes, forming a functional Ca2+ -release channel, the structural requirements for the tetramerization were studied...
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Inhibition of gamma ray-induced apoptosis by stimulatory heterotrimeric GTP binding protein involves Bcl-xL down-regulation in SH-SY5Y human neuroblastoma cells

Kim SY, Seo M, Oh JM, Cho EA, Juhnn YS

  • KMID: 1090961
  • Exp Mol Med.
  • 2007 Oct;39(5):583-593.
Heterotrimeric GTP-binding proteins (G proteins) transduce extracellular signals into intracellular signals by activating effector molecules including adenylate cyclases that catalyze cAMP formation, and thus regulate various cellular responses such as...
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Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons

Kim HJ, Im W, Kim S, Kim SH, Sung JJ, Kim M, Lee KW

  • KMID: 1090960
  • Exp Mol Med.
  • 2007 Oct;39(5):574-582.
Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are involved in neuronal death. However, the effect of altered calcium...
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WNKs: protein kinases with a unique kinase domain

Huang CL, Cha SK, Wang HR, Xie J, Cobb MH

  • KMID: 1090959
  • Exp Mol Med.
  • 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in...
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