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A novel way of therapeutic angiogenesis using an adeno-associated virus-mediated angiogenin gene transfer

Cho YH, Park H, Cho ES, Kim WJ, Kang BS, Park BY, Kim YJ, Lee YI, Chang SI, Park K

  • KMID: 1047093
  • Exp Mol Med.
  • 2007 Jun;39(3):412-418.
To develop a novel therapeutic angiogenesis for the treatment of cardiovascular diseases, angiogenin (ANG1) was examined as a potential therapeutic gene. An adeno-associated virus (AAV)-mediated gene delivery system was used...
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Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1

Kang JH, Kim SA, Chang SY, Hong S, Hong KJ

  • KMID: 1047092
  • Exp Mol Med.
  • 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression...
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Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle

Oh YS, Kim HJ, Ryu SJ, Cho KA, Park YS, Park H, Kim M, Kim CK, Park SC

  • KMID: 1047091
  • Exp Mol Med.
  • 2007 Jun;39(3):395-401.
It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in...
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Swim training improves leptin receptor deficiency-induced obesity and lipid disorder by activating uncoupling proteins

Oh KS, Kim EY, Yoon M, Lee CM

  • KMID: 1047090
  • Exp Mol Med.
  • 2007 Jun;39(3):385-394.
Leptin receptor deficiency causes morbid obesity and hyperlipidemia in mice. Since physical exercise enhances energy expenditure, it is an important part of successful weight-control regimens. We investigated the mechanism by...
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Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine

Lee MK, Kang SJ, Poncz M, Song KJ, Park KS

  • KMID: 1047089
  • Exp Mol Med.
  • 2007 Jun;39(3):376-384.
Dopamine (DA) is an oxidant that may contribute to the degeneration of dopaminergic neurons. The present study demonstrates that DA-induced cytotoxicity in human-derived neurotypic cells, SH-SY5Y, is prevented by resveratrol,...
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Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation

Hur GY, Lee SY, Lee SH, Kim SJ, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH

  • KMID: 1047088
  • Exp Mol Med.
  • 2007 Jun;39(3):367-375.
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the...
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Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast ancer risk in Korean women

Shin A, Kang D, Choi JY, Lee KM, Park SK, Noh DY, Ahn SH, Yoo KY

  • KMID: 1047087
  • Exp Mol Med.
  • 2007 Jun;39(3):361-366.
Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We evaluated the associations between two...
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Haloperidol and clozapine differentially regulate signals pstream of glycogen synthase kinase 3 in the rat frontal cortex

Roh MS, Seo MS, Kim Y, Kim SH, Jeon WJ, Ahn YM, Kang UG, Juhnn YS, Kim YS

  • KMID: 1047086
  • Exp Mol Med.
  • 2007 Jun;39(3):353-360.
Glycogen synthase kinase 3 (GSK3) was recently suggested to be a potential target of psychotropics used in psychiatric illnesses such as schizophrenia and bipolar disorder. Relevant studies have found that...
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TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice

Moon EY, Ryu SK

  • KMID: 1047085
  • Exp Mol Med.
  • 2007 Jun;39(3):343-352.
Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated...
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An inhibitory compound against the interaction between Galpha(s) and the third intracellular loop region of serotonin receptor subtype 6 (5-HT(6)) disrupts the signaling pathway of 5-HT(6)

Choi YH, Kang H, Lee WK, Kim T, Rhim H, Yu YG

  • KMID: 1047084
  • Exp Mol Med.
  • 2007 Jun;39(3):335-342.
Serotonin receptor subtype 6 (5-HT(6)) is a neurotransmitter receptor, which is involved in various brain functions such as memory and mood. It mediates signaling via the interaction with a stimulatory...
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Association between angiotensin-1 converting enzyme gene olymorphism and the metabolic syndrome in a Mexican opulation

Alvarez-Aguilar C, Enriquez-Ramirez ML, Figueroa-Nunez B, Gomez-Garcia A, Rodriguez-Ayala E, Moran-Moguel C, Farias-Rodriguez VM, Mino-Leon , Lopez-Meza JE

  • KMID: 1047083
  • Exp Mol Med.
  • 2007 Jun;39(3):327-334.
Metabolic Syndrome (MS) is recognized as a cluster of cardiovascular risk factors. All components of MS have a genetic base. Genes of the renin angiotensin system are potential candidate genes...
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Protective effects of fustin, a flavonoid from Rhus verniciflua tokes, on 6-hydroxydopamine-induced neuronal cell death

Park BC, Lee YS, Park HJ, Kwak MK, Yoo BK, Kim JY, Kim JA

  • KMID: 1047082
  • Exp Mol Med.
  • 2007 Jun;39(3):316-326.
6-Hydroxydopamine (6-OHDA) is a neurotoxin and is commonly used to generate experimental models of Parkinson's disease (PD). In this study, we investigated the signaling molecules involved in the 6-OHDA-induced cell...
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Effects of retinoic acid on ischemic brain injury-induced eurogenesis

Jung DS, Baek SY, Park KH, Chung YI, Kim HJ, Kim CD, Cho MK, Han ME, Park KP, Kim BS, Kim JB, Oh SO

  • KMID: 1047081
  • Exp Mol Med.
  • 2007 Jun;39(3):304-315.
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic...
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gp130 is important for the normal morphogenesis of Meckel's cartilage and subsequent mandibular development

Choi JW, Kim JT, Park JH, Park EK, Kim SY, Kwon TG, Kim EC, Shin HI

  • KMID: 1047080
  • Exp Mol Med.
  • 2007 Jun;39(3):295-303.
gp130-mediated signaling is involved in both chondrogenesis and osteogenesis, but its direct role in the formation of embryonic Meckel's cartilage and associated mandibular development has not yet been elucidated. In...
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Histamine and spontaneously released mast cell granules ffect the cell growth of human hepatocellular carcinoma cells

Lampiasi N, Azzolina A, Montalto G, Cervello M

  • KMID: 1047079
  • Exp Mol Med.
  • 2007 Jun;39(3):284-294.
The role of mast cells in tumor growth is still controversial. In this study we analyzed the effects of both histamine and pre-formed mediators spontaneously released by mast cells on...
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Capsaicin promotes the development of burst-forming nits-erythroid (BFU-E) from mouse bone marrow cells

Lee SA, Ryu YS, Choi HI, Han IS

  • KMID: 1047078
  • Exp Mol Med.
  • 2007 Jun;39(3):278-283.
Capsaicin, the pungent component of chilli peppers, is known to induce mediators of hematopoiesis. We investigated the effect of capsaicin on hematopoiesis in mouse progenitor cells. Treatment of mouse bone...
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Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells

Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, Chung HT

  • KMID: 1047077
  • Exp Mol Med.
  • 2007 Jun;39(3):267-277.
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is...
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Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury

Liu T, Ma Z, Que H, Li X, Ni Y, Jing S, Liu S

  • KMID: 1047076
  • Exp Mol Med.
  • 2007 Jun;39(3):255-266.
Spinal cord injury and regeneration involves transcriptional activity of many genes, of which many remain unknown. Using the rat spinal cord full- transection model, bioinformatics, cloning, expression assays, fusion proteins,...
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RNA polymerase II carboxy-terminal domain with multiple connections

Cho EJ

  • KMID: 1047075
  • Exp Mol Med.
  • 2007 Jun;39(3):247-254.
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of...
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