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The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain

Park HJ, Seo HJ, Kim HW, Kim JS, Hwang SY, Seong YS

  • KMID: 1091078
  • Exp Mol Med.
  • 2007 Dec;39(6):828-838.
KM-HN-1 is a C-terminal coiled-coil domain containing protein previously referred to as image clone MGC33607. This protein has been previously identified as a cancer/testis antigen and reported as nuclear and...
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ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion

Kim SY, Moon JH, Lee HG, Kim SU, Lee YB

  • KMID: 1091077
  • Exp Mol Med.
  • 2007 Dec;39(6):820-827.
Present study demonstrated that fibrillar beta-amyloid peptide (fAbeta(1-42)) induced ATP release, which in turn activated NADPH oxidase via the P2X(7) receptor (P2X(7)R). Reactive oxygen species (ROS) production in fAbeta(1-42)-treated microglia...
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Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo

Park KW, Lee HG, Jin BK, Lee YB

  • KMID: 1091076
  • Exp Mol Med.
  • 2007 Dec;39(6):812-819.
A degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is expressed in LPS-injected rat cerebral...
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Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population

Li CS, Zhang Q, Lim MK, Sheen DH, Shim SC, Kim JY, Lee SS, Yun KJ, Moon HB, Chung HT, Chae SC

  • KMID: 1091075
  • Exp Mol Med.
  • 2007 Dec;39(6):805-811.
The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and B cells through an induction of IkappaBbeta that results in repression of NF-kappaB activity. In...
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Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas

Choi B, Suh Y, Kim WH, Christa L, Park J, Bae CD

  • KMID: 1091074
  • Exp Mol Med.
  • 2007 Dec;39(6):796-804.
Gastric carcinoma is considered to be one of the most prevalent cancers worldwide. We have performed differential-display polymerase chain reaction (DD-PCR) in order to compare the gene expression profile of...
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Identification of a kidney-specific mouse organic cation transporter like-1 (mOCTL1)

Lee WK, Hwang JS, Yun CH, Cha SH

  • KMID: 1091073
  • Exp Mol Med.
  • 2007 Dec;39(6):787-795.
Organic ion transporters are expressed in various tissues that transport endogenous and exogenous compounds including their metabolites. There are organic anion transporter (OAT), organic cation transporter (OCT), organic anion transporter...
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Suppression of HIV-1 Tat-induced monocyte adhesiveness by a cell-permeable superoxide dismutase in astrocytes

Song HY, Ju SM, Lee JA, Kwon HJ, Eum WS, Jang SH, Choi SY, Park J

  • KMID: 1091072
  • Exp Mol Med.
  • 2007 Dec;39(6):778-786.
HIV-1 Tat is considered to be one of key players to facilitate monocyte entry into the CNS, which is characteristic feature of AIDS-related encephalitis and dementia. This study was performed...
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Comparative bioinformatics analysis of prion proteins isolated from reptile, rodent, ruminant, and human species

Ahn I, Son HS

  • KMID: 1091071
  • Exp Mol Med.
  • 2007 Dec;39(6):769-777.
Prion proteins (PrPs) are infectious pathogens that cause a group of invariably fatal, neurodegenerative diseases, including Creutzfeldt-Jakob disease, by means of an entirely novel mechanism. They are produced by various...
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A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha

Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Han HJ, Lee YR, Kim JS, Atlas D, Lee YC

  • KMID: 1091070
  • Exp Mol Med.
  • 2007 Dec;39(6):756-768.
Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity...
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Detection of homodimer formation of CD99 through extracelluar domain using bimolecular fluorescence complementation analysis

Choi G, Lee SW, Jung KC, Choi EY

  • KMID: 1091069
  • Exp Mol Med.
  • 2007 Dec;39(6):746-755.
Although various functions of CD99 have been reported, such as apoptosis and homotypic aggregation of thymocyte and transendothelial migration of immune cells, biochemical/molecular natures of CD99 are still elusive. Using...
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Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1

Lee KS, Lee KY, Kim SR, Park HS, Park SJ, Min KH, Cho CH, Koh GY, Park HS, Lee YC

  • KMID: 1091068
  • Exp Mol Med.
  • 2007 Dec;39(6):733-745.
Inflammation of the asthmatic airway is usually accompanied by increased vascular permeability and plasma exudation. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage. Recently, we developed a soluble,...
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Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme

Song MS, Jeong JS, Cho KS, Lee SW

  • KMID: 1091067
  • Exp Mol Med.
  • 2007 Dec;39(6):722-732.
A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in...
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Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells

Jung HW, Chung YS, Kim YS, Park YK

  • KMID: 1091066
  • Exp Mol Med.
  • 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as...
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Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death

Choi SC, Yoon SR, Park YP, Song EY, Kim JW, Kim WH, Yang Y, Lim JS, Lee HG

  • KMID: 1091065
  • Exp Mol Med.
  • 2007 Dec;39(6):705-714.
Although N-myc downstream regulated gene 2 (NDRG2) has been known to be a tumor suppressor gene, the function of this gene has not been elucidated. In the present study, we...
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The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma gene with serum osteoprotegerin levels in healthy Korean women

Rhee EJ, Oh KW, Yun EJ, Jung CH, Park CY, Lee WY, Oh ES, Baek KH, Kang MI, Park SW, Kim SW

  • KMID: 1091064
  • Exp Mol Med.
  • 2007 Dec;39(6):696-704.
Recent evidences suggest that the activation of peroxisome proliferator-activated receptor (PPAR)-gamma, which is an important transcriptional factor in adipocyte differentiation, also plays an important role in the bone microenvironment. The...
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Mass spectrometry based proteomic analysis of human stem cells: a brief review

Choi MY, An YJ, Kim SH, Roh SH, Ju HK, Hong SS, Park JH, Cho KJ, Choi DW, Kwon SW

  • KMID: 1091063
  • Exp Mol Med.
  • 2007 Dec;39(6):690-695.
Stem cells can give rise to various cell types and are capable of regenerating themselves over multiple cell divisions. Pluripotency and self-renewal potential of stem cells have drawn vast interest...
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DNA vaccines for cervical cancer: from bench to bedside

Hung CF, Monie A, Alvarez RD, Wu TC

  • KMID: 1091062
  • Exp Mol Med.
  • 2007 Dec;39(6):679-689.
More than 99% of cervical cancers have been associated with human papillomaviruses (HPVs), particularly HPV type 16. The clear association between HPV infection and cervical cancer indicates that HPV serves...
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