- Mass spectrometry based proteomic analysis of human stem cells: a brief review
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Choi MY, An YJ, Kim SH, Roh SH, Ju HK, Hong SS, Park JH, Cho KJ, Choi DW, Kwon SW
- KMID: 1091063
- Exp Mol Med.
- 2007 Dec;39(6):690-695.
Stem cells can give rise to various cell types and are capable of regenerating themselves over multiple cell divisions. Pluripotency and self-renewal potential of stem cells have drawn vast interest... -
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- Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme
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Song MS, Jeong JS, Cho KS, Lee SW
- KMID: 1091067
- Exp Mol Med.
- 2007 Dec;39(6):722-732.
A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in... -
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- The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain
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Park HJ, Seo HJ, Kim HW, Kim JS, Hwang SY, Seong YS
- KMID: 1091078
- Exp Mol Med.
- 2007 Dec;39(6):828-838.
KM-HN-1 is a C-terminal coiled-coil domain containing protein previously referred to as image clone MGC33607. This protein has been previously identified as a cancer/testis antigen and reported as nuclear and... -
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- Detection of homodimer formation of CD99 through extracelluar domain using bimolecular fluorescence complementation analysis
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Choi G, Lee SW, Jung KC, Choi EY
- KMID: 1091069
- Exp Mol Med.
- 2007 Dec;39(6):746-755.
Although various functions of CD99 have been reported, such as apoptosis and homotypic aggregation of thymocyte and transendothelial migration of immune cells, biochemical/molecular natures of CD99 are still elusive. Using... -
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- Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas
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Choi B, Suh Y, Kim WH, Christa L, Park J, Bae CD
- KMID: 1091074
- Exp Mol Med.
- 2007 Dec;39(6):796-804.
Gastric carcinoma is considered to be one of the most prevalent cancers worldwide. We have performed differential-display polymerase chain reaction (DD-PCR) in order to compare the gene expression profile of... -
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- Comparative bioinformatics analysis of prion proteins isolated from reptile, rodent, ruminant, and human species
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Ahn I, Son HS
- KMID: 1091071
- Exp Mol Med.
- 2007 Dec;39(6):769-777.
Prion proteins (PrPs) are infectious pathogens that cause a group of invariably fatal, neurodegenerative diseases, including Creutzfeldt-Jakob disease, by means of an entirely novel mechanism. They are produced by various... -
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- Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells
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Jung HW, Chung YS, Kim YS, Park YK
- KMID: 1091066
- Exp Mol Med.
- 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as... -
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- Identification of a kidney-specific mouse organic cation transporter like-1 (mOCTL1)
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Lee WK, Hwang JS, Yun CH, Cha SH
- KMID: 1091073
- Exp Mol Med.
- 2007 Dec;39(6):787-795.
Organic ion transporters are expressed in various tissues that transport endogenous and exogenous compounds including their metabolites. There are organic anion transporter (OAT), organic cation transporter (OCT), organic anion transporter... -
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- DNA vaccines for cervical cancer: from bench to bedside
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Hung CF, Monie A, Alvarez RD, Wu TC
- KMID: 1091062
- Exp Mol Med.
- 2007 Dec;39(6):679-689.
More than 99% of cervical cancers have been associated with human papillomaviruses (HPVs), particularly HPV type 16. The clear association between HPV infection and cervical cancer indicates that HPV serves... -
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- A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha
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Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Han HJ, Lee YR, Kim JS, Atlas D, Lee YC
- KMID: 1091070
- Exp Mol Med.
- 2007 Dec;39(6):756-768.
Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity... -
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- Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo
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Park KW, Lee HG, Jin BK, Lee YB
- KMID: 1091076
- Exp Mol Med.
- 2007 Dec;39(6):812-819.
A degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is expressed in LPS-injected rat cerebral... -
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- Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death
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Choi SC, Yoon SR, Park YP, Song EY, Kim JW, Kim WH, Yang Y, Lim JS, Lee HG
- KMID: 1091065
- Exp Mol Med.
- 2007 Dec;39(6):705-714.
Although N-myc downstream regulated gene 2 (NDRG2) has been known to be a tumor suppressor gene, the function of this gene has not been elucidated. In the present study, we... -
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- ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion
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Kim SY, Moon JH, Lee HG, Kim SU, Lee YB
- KMID: 1091077
- Exp Mol Med.
- 2007 Dec;39(6):820-827.
Present study demonstrated that fibrillar beta-amyloid peptide (fAbeta(1-42)) induced ATP release, which in turn activated NADPH oxidase via the P2X(7) receptor (P2X(7)R). Reactive oxygen species (ROS) production in fAbeta(1-42)-treated microglia... -
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- Suppression of HIV-1 Tat-induced monocyte adhesiveness by a cell-permeable superoxide dismutase in astrocytes
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Song HY, Ju SM, Lee JA, Kwon HJ, Eum WS, Jang SH, Choi SY, Park J
- KMID: 1091072
- Exp Mol Med.
- 2007 Dec;39(6):778-786.
HIV-1 Tat is considered to be one of key players to facilitate monocyte entry into the CNS, which is characteristic feature of AIDS-related encephalitis and dementia. This study was performed... -
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- Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1
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Lee KS, Lee KY, Kim SR, Park HS, Park SJ, Min KH, Cho CH, Koh GY, Park HS, Lee YC
- KMID: 1091068
- Exp Mol Med.
- 2007 Dec;39(6):733-745.
Inflammation of the asthmatic airway is usually accompanied by increased vascular permeability and plasma exudation. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage. Recently, we developed a soluble,... -
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- Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population
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Li CS, Zhang Q, Lim MK, Sheen DH, Shim SC, Kim JY, Lee SS, Yun KJ, Moon HB, Chung HT, Chae SC
- KMID: 1091075
- Exp Mol Med.
- 2007 Dec;39(6):805-811.
The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and B cells through an induction of IkappaBbeta that results in repression of NF-kappaB activity. In... -
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- The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma gene with serum osteoprotegerin levels in healthy Korean women
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Rhee EJ, Oh KW, Yun EJ, Jung CH, Park CY, Lee WY, Oh ES, Baek KH, Kang MI, Park SW, Kim SW
- KMID: 1091064
- Exp Mol Med.
- 2007 Dec;39(6):696-704.
Recent evidences suggest that the activation of peroxisome proliferator-activated receptor (PPAR)-gamma, which is an important transcriptional factor in adipocyte differentiation, also plays an important role in the bone microenvironment. The... -
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