- PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity
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Lee SJ, Lee JR, Hah HS, Kim YH, Ahn JH, Bae CD, Yang JM, Hahn MJ
- KMID: 756067
- Exp Mol Med.
- 2007 Aug;39(4):450-457.
Zinc finger protein 133 (ZNF133) is composed of a Kruppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain... -
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- Akt is involved in the inhibition of cell proliferation by EGF
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Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY
- KMID: 756072
- Exp Mol Med.
- 2007 Aug;39(4):491-498.
Axin is a negative regulator of the Wnt/beta-catenin pathway and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways... -
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- Toll-like receptor signal transduction
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Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S
- KMID: 756065
- Exp Mol Med.
- 2007 Aug;39(4):421-438.
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous pathogens. Activation of TLRs is a first line of defense of the immune system, leading to the activation... -
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- Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
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Lee EJ, Choi EM, Kim SR, Park JH, Kim H, Ha KS, Kim YM, Kim SS, Choe M, Kim JI, Han JA
- KMID: 756069
- Exp Mol Med.
- 2007 Aug;39(4):469-476.
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in... -
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- Expression of dendritic cell markers on cultured neutrophils and its modulation by anti-apoptotic and pro-apoptotic compounds
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Park HY, Jin JO, Song MG, Park JI, Kwak JY
- KMID: 756066
- Exp Mol Med.
- 2007 Aug;39(4):439-449.
Neutrophils are also known to acquire the characteristics of dendritic cells (DCs) under the appropriate conditions. In this study, neutrophils were cultivated in vitro in the presence or absence of... -
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- The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
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Choi HK, Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Ahn YH, Kim KS, Kim K, Yoon HG
- KMID: 756078
- Exp Mol Med.
- 2007 Aug;39(4):544-555.
We have investigated the function and mechanisms of the CARM1-SNF5 complex in T3-dependent transcriptional activation. Using specific small interfering RNAs (siRNA) to knock down coactivators in HeLa alpha2 cells, we... -
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- Mutation analysis of p31(comet) gene, a negative regulator of Mad2, in human hepatocellular carcinoma
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Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH
- KMID: 756074
- Exp Mol Med.
- 2007 Aug;39(4):508-513.
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment... -
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- Isolation of neural precursor cells from skeletal muscle tissues and their differentiation into neuron-like cells
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Park JS, Kim S, Han DK, Lee JY, Ghil SH
- KMID: 756071
- Exp Mol Med.
- 2007 Aug;39(4):483-490.
Skeletal muscle contains several precursor cells that generate muscle, bone, cartilage and blood cells. Although there are reports that skeletal muscle-derived cells can trans-differentiate into neural-lineage cells, methods for isolating... -
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- Na+-Ca2+ exchanger modulates Ca2+ content in intracellular Ca2+ stores in rat osteoblasts
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Jung SY, Park YJ, Park YJ, Cha SH, Lee MZ, Suh CK
- KMID: 756068
- Exp Mol Med.
- 2007 Aug;39(4):458-468.
Na+ -Ca2+ exchanger (NCX) transports Ca2+ coupled with Na+ across the plasma membrane in a bi-directional mode. Ca2+ flux via NCX mediates osteogenic processes, such as formation of extracellular matrix... -
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- Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells
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Sung YK, Park MK, Hong SH, Hwang SY, Kwack MH, Kim JC, Kim MK
- KMID: 756070
- Exp Mol Med.
- 2007 Aug;39(4):477-482.
Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified free arachidonic acid (AA) level in cells and the free AA is known to induce apoptosis. We have... -
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- Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages
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Cheon HJ, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J
- KMID: 756076
- Exp Mol Med.
- 2007 Aug;39(4):524-534.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototypic halogenated aromatic hydrocarbon (HAH), is known as one of the most potent toxicants. At least a part of its toxic effects appears to be derived from... -
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- Ischemic preconditioning in the rat hippocampus increases antioxidant activities but does not affect the level of hydroxyl radicals during subsequent severe ischemia
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Choi YS, Cho KO, Kim EJ, Sung KW, Kim SY
- KMID: 756079
- Exp Mol Med.
- 2007 Aug;39(4):556-563.
Several studies have demonstrated that ischemic preconditioning increases superoxide dismutase activity, but it is unclear how ischemic preconditioning affects events downstream of hydrogen peroxide production during subsequent severe ischemia and... -
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- Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha
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Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L
- KMID: 756077
- Exp Mol Med.
- 2007 Aug;39(4):535-543.
Insufficient intracellular fat oxidation is an important contributor to aging-related insulin resistance, while the precise mechanism underlying is unclear. AMP-activated protein kinase (AMPK) is an important regulator of intracellular fat... -
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- Expression of CCR2A, an isoform of MCP-1 receptor, is increased by MCP-1, CD40 ligand and TGF-beta in fibroblast like synoviocytes of patients with RA
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Cho ML, Yoon BY, Ju JH, Jung YO, Jhun JY, Park MK, Park SH, Cho CS, Kim HY
- KMID: 756073
- Exp Mol Med.
- 2007 Aug;39(4):499-507.
Cytokine and chemokine receptors play a key role in inflammation caused by rheumatoid arthritis (RA). Two isoforms of human CC chemokine receptor R2 (CCR2), the receptor of monocyte chemoattractant protein... -
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- TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy
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Kim SM, Kim N, Lee S, Kim DK, Lee YM, Ahn SH, Song JH, Choi BK, Wu C, Jung KY
- KMID: 756075
- Exp Mol Med.
- 2007 Aug;39(4):514-523.
TGF-beta1-induced glomerular mesangial cell (GMC) injury is a prominent characteristic of renal pathology in several kidney diseases, and a ternary protein complex consisting of PINCH-1, integrin-linked kinase (ILK) and alpha-parvin... -
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