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Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression

Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C

  • KMID: 1094665
  • Exp Mol Med.
  • 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated...
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Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production

Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM

  • KMID: 1094664
  • Exp Mol Med.
  • 2007 Apr;39(2):230-238.
Colchicine has been shown to regulate the expression of inflammatory gene, but this compound possesses much weaker anti-inflammatory activity. In this study, we synthesized a new colchicine derivative CT20126 and...
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Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, Kim SS, Ha J

  • KMID: 1094663
  • Exp Mol Med.
  • 2007 Apr;39(2):222-229.
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of...
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Trichostatin A-mediated upregulation of p21

Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM

  • KMID: 1094662
  • Exp Mol Med.
  • 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about...
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Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif

Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J

  • KMID: 1094661
  • Exp Mol Med.
  • 2007 Apr;39(2):205-212.
Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate...
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Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells

Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW

  • KMID: 1094660
  • Exp Mol Med.
  • 2007 Apr;39(2):195-204.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle attachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of...
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Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins

Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS

  • KMID: 1094659
  • Exp Mol Med.
  • 2007 Apr;39(2):185-194.
Phytosphingosine-1-phosphate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38...
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CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta

Oh KI, Kim BK, Ban YL, Choi EY, Jung KC, Lee IS, Park SH

  • KMID: 1094658
  • Exp Mol Med.
  • 2007 Apr;39(2):176-184.
We investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or...
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Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo

Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S

  • KMID: 1094657
  • Exp Mol Med.
  • 2007 Apr;39(2):170-175.
The aims of this study were to evaluate the expression of enhanced green fluorescent protein (EGFP) driven by 6 different promoters, including cytomegalovirus IE enhancer and chicken beta-actin promoter (CAG),...
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A point mutant of apolipoprotein A-I, V156K, exhibited potent anti-oxidant and anti-atherosclerotic activity in hypercholesterolemic C57BL/6 mice

Cho KH, Park SH, Han JM, Kim HC, Chung YJ, Choi I, Kim JR

  • KMID: 1094656
  • Exp Mol Med.
  • 2007 Apr;39(2):160-169.
In our previous study, two point mutants of apolipoprotein A-I, designated V156K and A158E, revealed peculiar characteristics in their lipid-free and lipid-bound states. In order to determine the putative therapeutic...
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Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation

Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH

  • KMID: 1094655
  • Exp Mol Med.
  • 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma...
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Curcumin reduces cold storage-induced damage in human cardiac myoblasts

Abuarqoub , Green CJ, Foresti R, Motterlini R

  • KMID: 1094654
  • Exp Mol Med.
  • 2007 Apr;39(2):139-148.
Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to...
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p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells

Ko J, Yun CY, Lee JS, Kim JH, Kim IS

  • KMID: 1094653
  • Exp Mol Med.
  • 2007 Apr;39(2):129-138.
9-cis-retinoic acid (9CRA) plays an important role in the immune response; this includes cytokine production and cell migration. We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1...
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