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Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells

Lee E, Choi MK, Han IO, Lim SJ

  • KMID: 1094159
  • Exp Mol Med.
  • 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells...
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Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer

Kang S, Ju W, Kim JW, Park NH, Song YS, Kim SC, Park SY, Kang SB, Lee HP

  • KMID: 1094158
  • Exp Mol Med.
  • 2006 Jun;38(3):320-324.
ERCC1 is a DNA repair gene and has been associated with resistance to DNA damaging agents. In this study we hypothesized that a polymorphism of ERCC1 Asn118Asn (C->T) might affect...
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Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures

Eun SY, Kim EH, Kang KS, Kim HJ, Jo SA, Kim SJ, Jo SH, Kim SJ, Blackshear PJ, Kim J

  • KMID: 1094157
  • Exp Mol Med.
  • 2006 Jun;38(3):310-319.
Myristoylated alanine-rich C kinase substrate (MARCKS) is a widely distributed protein kinase C (PKC) substrate and has been implicated in actin cytoskeletal rearrangement in response to extracellular stimuli. Although MARCKS...
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Analysis of the variations in IL-28RA gene and their association with allergic rhinitis

Chae SC, Park YR, Li CS, Lee JH, Yang YS, Zhang Q, Kim KS, Chung HT

  • KMID: 1094156
  • Exp Mol Med.
  • 2006 Jun;38(3):302-309.
IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene. We scanned the...
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The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress

Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI

  • KMID: 1094155
  • Exp Mol Med.
  • 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic...
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Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation

Kim EY, Lee EN, Lee J, Park HJ, Chang CY, Jung DY, Choi SY, Lee SK, Joh JW, Kim SJ

  • KMID: 1094154
  • Exp Mol Med.
  • 2006 Jun;38(3):284-294.
Blockade of signal 1 or 2 for T-cell activation by the use of anti-CD45RB and anti-CD154 monoclonal antibodies (mAb) (two-signal blockade) has been proven effective in preventing or delaying graft...
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Tissue engineering of heart valves by recellularization of glutaraldehyde-fixed porcine valves using bone marrow-derived cells

Kim SS, Lim SH, Cho SW, Gwak SJ, Hong YS, Chang BC, Park MH, Song KW, Choi CY, Kim BS

  • KMID: 1094153
  • Exp Mol Med.
  • 2006 Jun;38(3):273-283.
To increase the biocompatibility and durability of glutaraldehyde (GA)-fixed valves, a biological coating with viable endothelial cells (ECs) has been proposed. However, stable EC layers have not been formed successfully...
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Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain

Kim SK, Choi JH, Suh PG, Chang JS

  • KMID: 1094152
  • Exp Mol Med.
  • 2006 Jun;38(3):265-272.
Phosphoinositide-specific phospholipase C-gamma1 (PLC-gamma1) has two pleckstrin homology (PH) domains: an amino-terminal domain (PH1) and a split PH domain (PH2). Here, we show that overlay assay of bovine brain tubulin...
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Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1

Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH

  • KMID: 1094151
  • Exp Mol Med.
  • 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances...
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Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas

Cho YG, Kim CJ, Song JH, Rhie DJ, Park YK, Kim SY, Nam SW, Yoo NJ, Lee JY, Park WS

  • KMID: 1094150
  • Exp Mol Med.
  • 2006 Jun;38(3):247-255.
The potassium channels are ubiquitous multisubunit membrane proteins, and potassium-dependent alterations in the membrane potential play an important role in the proliferation of many types of cells. This study analyzed...
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Expression of hepatitis C virus nonstructural 4B in transgenic mice

Wang AG, Moon HB, Kim JM, Hwang SB, Yu DY, Lee DS

  • KMID: 1094149
  • Exp Mol Med.
  • 2006 Jun;38(3):241-246.
Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated...
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Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells

Du ZX, Zhang HY, Gao DX, Wang HQ, Li YJ, Liu GL

  • KMID: 1094148
  • Exp Mol Med.
  • 2006 Jun;38(3):230-240.
Suvivin is a novel member of the inhibitor of apoptosis protein (IAP) family, which is known to be over-expressed in various carcinomas and associated with their biologically aggressive characteristics. The...
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An antioxidant modulates expression of receptor activator of NF-kappaB in asthma

Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC

  • KMID: 1094147
  • Exp Mol Med.
  • 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,...
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Delayed allograft rejection by the suppression of class II transactivator

Kim TW, Choi YM, Seo JN, Kim JH, Suh YH, Chung DH, Jung KC, Oh KI

  • KMID: 1094146
  • Exp Mol Med.
  • 2006 Jun;38(3):210-216.
We examined the effect of class II transactivator (CIITA) down-modulation on allograft rejection. To inhibit the function of CIITA, we constructed a series of CIITA mutants and found one exhibiting...
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Heterogeneous nuclear ribonuclear protein C is increased in the celecoxib-induced growth inhibition of human oral squamous cell carcinoma

Lee EJ, Kim SH, Kwark YE, Kim J

  • KMID: 1094145
  • Exp Mol Med.
  • 2006 Jun;38(3):203-209.
Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) that is a critical factor in carcinogenesis, but precise mechanism of its action remains to be elucidated. Here we evaluated the inhibitory...
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Characterization of a brain tumor cell line established from transgenic mice expressing the vasopressin SV-40 T antigen

Kim SH, Kim MO, Lee SR, Kim KS, Lee TH, Lee HT, Ha JH, Kim TY, Ryoo ZY

  • KMID: 1094144
  • Exp Mol Med.
  • 2006 Jun;38(3):196-202.
We previously reported that transgenic mice produced with a transgene consisting of the SV40 T antigen and vasopressin without the 3'-flanking region exhibit brain tumors and lymphoma. In this study,...
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The role of the alpha4 integrin-paxillin interaction in regulating leukocyte trafficking

Rose DM

  • KMID: 1094143
  • Exp Mol Med.
  • 2006 Jun;38(3):191-195.
The movement of leukocytes from the blood into peripheral tissues is a central feature of immune surveillance, but also contributes to the pathogenesis of inflammatory and autoimmune diseases. Integrins are...
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