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Naltrexone influences protein kinase C epsilon and integrin alpha7 activity in SH-SY5Y neuroblastoma cells

Oh DY, Jung KH, Yang BH, Lee JS, Choi IG, Chai YG

  • KMID: 1105282
  • Exp Mol Med.
  • 2006 Feb;38(1):100-106.
Alcohol influences the neuroadaptation of brain cells where receptors and enzymes like protein kinase C (PKC) exist. Naltrexone acts on opioid receptors. However, other mechanisms of action remain unknown. We...
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Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor

Kim J, Choi WS, Kim HJ, Kwon B

  • KMID: 1105281
  • Exp Mol Med.
  • 2006 Feb;38(1):94-99.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive...
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Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG

  • KMID: 1105280
  • Exp Mol Med.
  • 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,...
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Impaired responses of leukemic dendritic cells derived from a human myeloid cell line to LPS stimulation

Kim KD, Choi SC, Noh YW, Kim JW, Paik SG, Yang Y, Kim KI, Lim JS

  • KMID: 1105279
  • Exp Mol Med.
  • 2006 Feb;38(1):72-84.
Several myeloid leukemia-derived cells have been reported to possess the ability to differentiate into dendritic cells (DC). MUTZ-3, a myeloid leukemia cell line, responds to GM-CSF, IL-4 and TNF-alpha, and...
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Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells

Boo YC

  • KMID: 1105278
  • Exp Mol Med.
  • 2006 Feb;38(1):63-71.
Fluid shear stress plays a critical role in vascular health and disease. While protein kinase A (PKA) has been implicated in shear-stimulated signaling events in endothelial cells, it remains unclear...
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Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells

Ahn BH, Min G, Bae YS, Bae YS, Min DS

  • KMID: 1105277
  • Exp Mol Med.
  • 2006 Feb;38(1):55-62.
Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and...
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Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Lee KJ, Kim SJ, Kim SW, Choi SH, Shin YC, Park SH, Moon BH, Cho E, Lee MS, Choi SH, Chun BG, Shin KH

  • KMID: 1105276
  • Exp Mol Med.
  • 2006 Feb;38(1):44-54.
New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not...
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The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity

Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H

  • KMID: 1105275
  • Exp Mol Med.
  • 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation...
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Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines

Lee KH, Choi EY, Kim MK, Hyun MS, Jang BI, Kim TN, Kim SW, Song SK, Kim JH, Kim JR

  • KMID: 1105274
  • Exp Mol Med.
  • 2006 Feb;38(1):27-35.
The regulatory mechanisms for the proliferation and the particular invasive phenotypes of stomach cancers are not still fully understood. Up-regulations of hepatocytes growth factor (HGF), its receptor (c-Met), and urokinase-type...
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Structure-activity relationships of anti-HIV-1 peptides with disulfide linkage between D- and L-cysteine at positions i and i+3, respectively, derived from HIV-1 gp41 C-peptide

Lee MK, Kim HK, Lee TY, Hahm KS, Kim KL

  • KMID: 1105273
  • Exp Mol Med.
  • 2006 Feb;38(1):18-26.
The constrained alpha-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an alpha-helical structure are located close together, therefore D-Cys (dC) and...
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Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death

Choi YK, Kim TK, Kim CJ, Lee JS, Oh SY, Joo HS, Foster DN, Hong KC, You S, Kim H

  • KMID: 1105272
  • Exp Mol Med.
  • 2006 Feb;38(1):11-17.
The mitochondrial pathway of swine influenza virus (SIV)-induced apoptosis was investigated using porcine kidney (PK-15) cells, swine testicle (ST) cells, and HeLa cervical carcinoma cells which are known not to...
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Regulation of Wnt signaling by protein-protein interaction and post-translational modifications

Kikuchi A, Kishida S, Yamamoto H

  • KMID: 1105271
  • Exp Mol Med.
  • 2006 Feb;38(1):1-10.
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic beta-catenin and then the...
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