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Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells

Kim BW, Son H

  • KMID: 1115952
  • Exp Mol Med.
  • 2006 Dec;38(6):732-738.
It has been shown that neural cell adhesion molecule (NCAM)-induced neuronal differentiation is extracellular signal-regulated kinase (ERK)-dependent. However, an involvement of the mitogen activated protein kinase (MAPK) kinase (MEK), an...
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No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population

Ahn K, Kim E, Kwon YA, Kim DK, Lee JE, Jo SA

  • KMID: 1115951
  • Exp Mol Med.
  • 2006 Dec;38(6):727-731.
The polymorphism at codon 129 (M129V) of the human prion protein gene (PRNP) is a known risk factor for Creutzfeldt-Jakob disease (CJD) in Caucasians. There are few reports of this...
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Discovery of a small-molecule inhibitor for kidney ADP-ribosyl cyclase: Implication for intracellular calcium signal mediated by cyclic ADP-ribose

Nam TS, Choi SH, Rah SY, Kim SY, Jang W, Im MJ, Kwon HJ, Kim UH

  • KMID: 1115950
  • Exp Mol Med.
  • 2006 Dec;38(6):718-726.
ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca2+-mobilizing second messenger, cyclic ADP- ribose (cADPR), from beta-NAD+. A prototype of mammalian ADPR-cyclases is a lymphocyte antigen CD38. Accumulating evidence indicates that ADPR-cyclases other...
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Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts

Lee KM

  • KMID: 1115949
  • Exp Mol Med.
  • 2006 Dec;38(6):703-717.
Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these...
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Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS, Shin HD

  • KMID: 1115948
  • Exp Mol Med.
  • 2006 Dec;38(6):694-702.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the...
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Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence

Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH

  • KMID: 1115947
  • Exp Mol Med.
  • 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric...
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The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways

Shin SY, Lee JH, Min B, Lee YH

  • KMID: 1115946
  • Exp Mol Med.
  • 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated...
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Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells

Kwak DH, Yu K, Kim SM, Lee DH, Kim SM, Jung JU, Seo JW, Kim N, Lee SK, Jung KY, You H, Kim HA, Choo YK

  • KMID: 1115945
  • Exp Mol Med.
  • 2006 Dec;38(6):668-676.
Stem cells are used for the investigation of developmental processes at both cellular and organism levels and offer tremendous potentials for clinical applications as an unlimited source for transplantation. Gangliosides,...
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Heterozygosities of 735 microsatellite markers and background linkage disequilibrium in the Korean population

Lee KA, Kim JW

  • KMID: 1115944
  • Exp Mol Med.
  • 2006 Dec;38(6):662-667.
Suitability of a specific population for linkage disequilibrium mapping studies of complex traits may be assessed by investigating the background linkage disequilibrium (BLD). We are unaware of studies for quantifying...
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Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria

Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS

  • KMID: 1115943
  • Exp Mol Med.
  • 2006 Dec;38(6):652-661.
Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine b-synthase (CBS). The major clinical symptoms of this disease are mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms,...
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Epidemiological comparisons of codon usage patterns among HIV-1 isolates from Asia, Europe, Africa and the Americas

Ahn I, Son HS

  • KMID: 1115942
  • Exp Mol Med.
  • 2006 Dec;38(6):643-651.
To investigate the genomic properties of HIV-1, we collected 3,081 sequences from the HIV Sequence Database. The sequences were categorized according to sampling region, country, year, subtype, gene name, and...
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zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells

Yee SB, Baek SJ, Park HT, Jeong SH, Jeong JH, Kim TH, Kim JM, Jeong BK, Park BS, Kwon TK, Yoon I, Yoo YH

  • KMID: 1115941
  • Exp Mol Med.
  • 2006 Dec;38(6):634-642.
In a preliminary study, we found that benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD- fmk), unlike Boc-aspartyl(OMe)-fluoromethylketone (BocD-fmk), at usual dosage could not prevent genistein-induced apoptosis of p815 mastocytoma cells. This study was undertaken to...
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p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line

Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J

  • KMID: 1115940
  • Exp Mol Med.
  • 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known...
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Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway

Kim HR, Kim EJ, Yang SH, Jeong ET, Park C, Lee JH, Youn MJ, So HS, Park R

  • KMID: 1115939
  • Exp Mol Med.
  • 2006 Dec;38(6):616-624.
Trichostatin A (TSA), originally developed as an antifungal agent, is one of potent histone deacetylase (HDAC) inhibitors, which are known to cause growth arrest and apoptosis induction of transformed cells,...
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4-1BB (CD137) signals depend upon CD28 signals in alloimmune responses

Lee EA, Kim JE, Seo JH, Kwon BS, Nam SH, Kwon B, Cho HR

  • KMID: 1115938
  • Exp Mol Med.
  • 2006 Dec;38(6):606-615.
Our previous study has demonstrated that there is a significant delay of Balb/c cardiac allograft rejection in the C57BL/6 4-1BB-deficient knockout recipient. In this study, we examined the effect of...
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Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte

Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK, Do MS

  • KMID: 1115937
  • Exp Mol Med.
  • 2006 Dec;38(6):599-605.
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the...
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Efficient amplification of melanoma-specific CD8+ T cells using artificial antigen presenting complex

Chang J

  • KMID: 1115936
  • Exp Mol Med.
  • 2006 Dec;38(6):591-598.
In vitro large amplification of tumor-specific cytotoxic T lymphocytes (CTLs) and adoptive transfer of these cells is one of the most promising approaches to treat malignant diseases in which an...
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