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Detection of single nucleotide insertion of BCR/ABL region in imatinib-resistant human myelogenous leukemia SR-1 cells

Park TH, Kwon HC, Kim HJ, Han JY, Jeong JS, Han H, Seo CY, Kwak JY, Park JI

  • KMID: 1089462
  • Exp Mol Med.
  • 2005 Oct;37(5):507-511.
Imatinib mesylate is a selective Bcr/Abl kinase inhibitor and an effective anticancer agent for Bcr/Abl-positive chronic myelogenous leukemia. Most patients in chronic phase maintain durable responses; however, many in blast...
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Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Lim HW, Hong S, Jin W, Lim S, Kim SJ, Kang HJ, Park EH, Ahn K, Lim CJ

  • KMID: 1089461
  • Exp Mol Med.
  • 2005 Oct;37(5):497-506.
Reactive oxygen species (ROS) are involved in a diversity of important phenomena in the process of tumor development. To investigate the alterations of oxidative stress and their related systems in...
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Coordinated transcriptional regulation of calmegin, a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase

Kim DH, Shim JS, Kwon HJ

  • KMID: 1089460
  • Exp Mol Med.
  • 2005 Oct;37(5):492-496.
Calmegin is a testis-specific molecular chaperon playing a key role in spermatogenesis. However, the transcriptional regulatory mechanisms for calmegin expression are entirely unknown. Herein, we revealed that calmegin is transcriptionally...
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Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53

Chae HD, Yun J, Shi D

  • KMID: 1089459
  • Exp Mol Med.
  • 2005 Oct;37(5):488-491.
NF-Y transcription factor binds to CCAAT boxes on promoters of cell cycle regulatory genes such as cdc2, cyclin B, cdc25C, and cyclin A. We previously reported that the DNA binding...
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Centrosome amplification and multinuclear phenotypes are Induced by hydrogen peroxide

Chae S, Yun C, Um H, Lee JH, Cho H

  • KMID: 1089458
  • Exp Mol Med.
  • 2005 Oct;37(5):482-487.
Multinucleated cells resulted from mitosis defect have been noted in pathophysiological states of the cells such as inflammation, senescence and cancer. Since oxidative stress has been known to correlate with...
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Alternative therapy of earth elements increases the chondroprotective effects of chondroitin sulfate in mice

Caraglia M, Beninati S, Giuberti G, D'Alessandro A, Lentini A, Abbruzzese A, Bove G, Landolfi F, Rossi F, Lampa E, Costantino M

  • KMID: 1089457
  • Exp Mol Med.
  • 2005 Oct;37(5):476-481.
The administration of mineral sulphur water is an alternative experimental approach for the treatment of rheumatic diseases, such as osteoarthritis (OA), that cause the degeneration of bone and cartilage and...
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Menin represses JunD transcriptional activity in protein kinase Ctheta-mediated Nur77 expression

Kim H, Lee JE, Kim BY, Cho EJ, Kim ST, Youn HD

  • KMID: 1089456
  • Exp Mol Med.
  • 2005 Oct;37(5):466-475.
TCR signaling leading to thymocyte apoptosis is mediated through the expression of the Nur77 family of orphan nuclear receptors. It has been shown that the Nur77 promoter is activated by...
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The extracellular calcium sensing receptor is expressed in mouse mesangial cells and modulates cell proliferation

Kwak JO, Kwak J, Kim HW, Oh KJ, Kim YT, Jung SM, Cha SH

  • KMID: 1089455
  • Exp Mol Med.
  • 2005 Oct;37(5):457-465.
The extracellular calcium sensing receptor (CaSR) belongs to the type III family of G-protein-coupled receptors, a family that comprises the metabotropic glutamate receptor and the putative vomeronasal organ receptors. The...
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Cardiac expression profiles of the naked DNA vectors encoding vascular endothelial growth factor and basic fibroblast growth factor

Lee JS, Byun J, Kim JM, Kim CY, Kim BM, Chung JH, Jang Y, Kim DK

  • KMID: 1089454
  • Exp Mol Med.
  • 2005 Oct;37(5):447-456.
We investigated expression profiles and biological effects of the naked DNA vectors in the heart. To this end, naked DNA vector was injected into the apex of the beating rat...
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Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress

Whang WK, Park HS, Ham I, Oh M, Namkoong H, Kim HK, Hwang DW, Hur SY, Kim TE, Park YG, Kim JR, Kim JW

  • KMID: 1089453
  • Exp Mol Med.
  • 2005 Oct;37(5):436-446.
Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence...
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Heat shock protein 27 interacts with vimentin and prevents insolubilization of vimentin subunits induced by cadmium

Lee JS, Zhang MH, Yun EK, Geum D, Kim K, Kim TH, Lim YS, Seo JS

  • KMID: 1089452
  • Exp Mol Med.
  • 2005 Oct;37(5):427-435.
Vimentin is an intermediate filament that regulates cell attachment and subcellular organization. In this study, vimentin filaments were morphologically altered, and its soluble subunits were rapidly reduced via cadmium chloride...
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Involvement of protein kinase C pathway in UVC-stimulated phospholipase D2 activity in Vero 76 cells

Kim S, Choi MS, Choi MU

  • KMID: 1089451
  • Exp Mol Med.
  • 2005 Oct;37(5):418-426.
Phospholipase D (PLD) activity is known to be related to oxidant-induced cellular signaling and membrane disturbance. Previously, an induction of PLD activity in various cell lines by X-ray irradiation was...
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Roles of TNF-alpha and IgE in the late phase of contact hypersensitivity induced by trimellitic anhydride

Chai OH, Lee HK, Lee YC, Lee MS, Han EH, Kim HT, Song CH

  • KMID: 1089450
  • Exp Mol Med.
  • 2005 Oct;37(5):408-417.
Trimellitic anhydride (TMA) is widely used industrially to make epoxy and alkyd resins, plasticizers and surfactants. The purpose of this study was to investigate whether contact hypersensitivity (CHS) is induced...
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Efficient culture system for human embryonic stem cells using autologous human embryonic stem cell-derived feeder cells

Yoo SJ, Yoon BS, Kim JM, Song JM, Roh SI, You S, Yoon HS

  • KMID: 1089449
  • Exp Mol Med.
  • 2005 Oct;37(5):399-407.
Human embryonic stem cells (hESCs) need feeder cells for their maintenance in an undifferentiated state. In conventional culture systems, mouse embryonic fibroblasts (MEFs) serve as feeder cells to maintain hESCs....
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PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells

Hwang PH, Kim SY, Lee JC, Kim SJ, Yi HK, Lee DY

  • KMID: 1089448
  • Exp Mol Med.
  • 2005 Oct;37(5):391-398.
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of advanced and metastatic cancers. Its major function is likely to be the phosphatase activity that regulates the...
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Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells

Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH, Yook JI

  • KMID: 1089447
  • Exp Mol Med.
  • 2005 Oct;37(5):379-390.
Since genetic abnormalities of human cancer are greatly geographically dependent, cultural and environmental backgrounds are thought to be closely related to the carcinogenic process. In the present study, eight human...
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