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Sec13 induces genomic instability in U2OS cells

Sihn CR, Suh EJ, Lee KH, Kim SH

  • KMID: 1056239
  • Exp Mol Med.
  • 2005 Jun;37(3):255-260.
Sec13p has been known as an endoplasmic reticulum-Golgi transport protein. Recently, it has also been shown to be required for the formation of septation in the fission yeast Schizosaccharomyces pombe....
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Identification of a putative transactivation domain in human Nanog

Oh JH, Do HJ, Yang HM, Moon SY, Cha KY, Chung HM, Kim JH

  • KMID: 1056238
  • Exp Mol Med.
  • 2005 Jun;37(3):250-254.
Nanog is a newly identified divergent homeodomain protein that directs the infinite propagation and sustains the pluripotency of embryonic stem cells. It has been reported that murine Nanog has two...
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Antitumor immunity induced by tumor cells engineered to express a membrane-bound form of IL-2

Chang MR, Lee WH, Choi JW, Park SO, Paik SG, Kim YS

  • KMID: 1056237
  • Exp Mol Med.
  • 2005 Jun;37(3):240-249.
Transduction of cytokine gene into tumor cells is a promising method of tumor therapy, but the value is limited by accompanying side effects. To focus antitumor immune response to tumor...
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Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells

Hong IK, Kim YM, Jeoung DI, Kim KC, Lee H

  • KMID: 1056236
  • Exp Mol Med.
  • 2005 Jun;37(3):230-239.
Expression of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), which correlates with tumor invasion and metastasis, has been known to be regulated by several intracellular signaling pathways. Since the CD9...
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O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes

Park SY, Ryu J, Lee W

  • KMID: 1056235
  • Exp Mol Med.
  • 2005 Jun;37(3):220-229.
It has been known that O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins plays an important role in transcription, translation, nuclear transport and signal transduction. The increased flux of glucose through the...
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Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line

Park M, Park H, Kim WH, Cho H, Lee JH

  • KMID: 1056234
  • Exp Mol Med.
  • 2005 Jun;37(3):213-219.
Autocrine stimulation via coexpression of hepatocyte growth factor (HGF) and its receptor (Met) has been reported in many human sarcomas, but few in carcinomas. In this report, we found that...
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Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney

Kwak JO, Kim HW, Oh KJ, Kim DS, Han KO, Cha SH

  • KMID: 1056233
  • Exp Mol Med.
  • 2005 Jun;37(3):204-212.
The organic anion transporters (OAT) have recently been identified. Although the some transport properties of OATs in the kidney have been verified, the regulatory mechanisms for OAT's functions are still...
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COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells

Choi EM, Kwak SJ, Kim YM, Ha KS, Kim JI, Lee SW, Han JA

  • KMID: 1056232
  • Exp Mol Med.
  • 2005 Jun;37(3):199-203.
Cyclooxygenase-2 (COX-2) has been reported to be associated with tumor development and progression as well as to protect cells from apoptosis induced by various cellular stresses. Through a tetracycline-regulated COX-2...
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In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

La S, Kim E, Kwon B

  • KMID: 1056231
  • Exp Mol Med.
  • 2005 Jun;37(3):193-198.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive...
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Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets

Cho JW, Park K, Kweon GR, Jang BC, Baek WK, Suh MH, Kim CW, Lee KS, Suh SI

  • KMID: 1056230
  • Exp Mol Med.
  • 2005 Jun;37(3):186-192.
Ultraviolet B (UVB) irradiation of skin induces an acute inflammation. Cyclooxygenase-2 (COX-2) protein plays key roles in acute inflammation in UVB-irradiated keratinocyte cell line HaCaT. Recently, curcumin has been regarded...
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15-Deoxy-delta12,14-PGJ2inhibits IL-6-induced Stat3 phosphorylation in lymphocytes

Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon HJ, Um JW, Sohn J, Song GG, Ji JD

  • KMID: 1056229
  • Exp Mol Med.
  • 2005 Jun;37(3):179-185.
15-deoxy-delta12,14-PGJ2(15d-PGJ2) is a natural ligand that activates the peroxisome proliferators-activated receptor (PPAR) gamma, a member of nuclear receptor family implicated in regulation of lipid metabolism and adipocyte differentiation. Recent studies...
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Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts

Ha H, Pak Y

  • KMID: 1056228
  • Exp Mol Med.
  • 2005 Jun;37(3):169-178.
We investigated glucose uptake and the translocation of Akt and caveolin-3 in response to insulin in H9c2 cardiomyoblasts exposed to an experimental insulin resistance condition of 100 nM insulin in...
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Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity

Song M, Kim MJ, Ha S, Park JB, Ryu SH, Suh PG

  • KMID: 1056227
  • Exp Mol Med.
  • 2005 Jun;37(3):161-168.
Phospholipase C-gamma1, containing two SH2 and one SH3 domains which participate in the interaction between signaling molecules, plays a significant role in the growth factor-induced signal transduction. However, the role...
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Increased lysine N-methylation of a 23-kDa protein during hepatic regeneration

Choi YB, Ko MH, Shin CH, Kim KS, Hong KM, Paik MK, Park DE

  • KMID: 1056226
  • Exp Mol Med.
  • 2005 Jun;37(3):155-160.
The methylation of a 23-kDa nuclear protein increased after partial hepatectomy and methylation returned to basal levels after the initial stage of regeneration. The methylating enzyme was partially purified from...
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Genotype-Phenotype correlation of SMN locus genes in spinal muscular atrophy patients from India

Kesari A, Idris MM, Chandak GR, Mittal B

  • KMID: 1056225
  • Exp Mol Med.
  • 2005 Jun;37(3):147-154.
Spinal muscular atrophy has been classified into four groups based on the age of onset and clinical severity of the disease. Homozygous deletion in SMN1 gene causes the disease but...
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