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Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27

Seo YJ, Jeon MH, Lee JH, Lee YJ, Youn HJ, Ko JH, Lee JH

  • KMID: 1116208
  • Exp Mol Med.
  • 2005 Dec;37(6):624-630.
Bis (Bag-3, CAIR), a Bcl-2-interacting protein, promotes the anti-apoptotic activity of Bcl-2 and increased levels of Bis have been observed in several disease models. The involvement of Bcl-2 and some...
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CKbeta8-1 alters expression of cyclin E in colony forming units-granulocyte macrophage (CFU-GM) lineage from human cord blood CD34 + cells

Noh EK, Ra JS, Lee SA, Kwon BS, Han IS

  • KMID: 1116207
  • Exp Mol Med.
  • 2005 Dec;37(6):619-623.
A C6 beta-chemokine, CKbeta8-1, suppressed the colony formation of CD34 + cells of human cord blood (CB). Molecular mechanisms involved in CKbeta8-1-medicated suppression of colony formation of CD34 + cells...
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Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells

Chin C, Bae JH, Kim MJ, Hwang JY, Kim SJ, Yoon MS, Lee MK, Kim DW, Chung BS, Kang CD, Kim SH

  • KMID: 1116206
  • Exp Mol Med.
  • 2005 Dec;37(6):608-618.
Here we determined which radiation-responsive genes were altered in radioresistant CEM/IR and FM3A/IR variants, which showed higher resistance to irradiation than parental human leukemia CEM and mouse mammary carcinoma FM3A...
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Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog

Kim JS, Kim J, Kim BS, Chung HY, Lee YY, Park CS, Lee YS, Lee YH, Chung IY

  • KMID: 1116205
  • Exp Mol Med.
  • 2005 Dec;37(6):601-607.
Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Here, we report the identification of an alternatively-spliced variant of nanog....
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Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells

Namkoong S, Lee SJ, Kim CK, Kim YM, Chung HT, Lee H, Han JA, Ha KS, Kwon YG, Kim YM

  • KMID: 1116204
  • Exp Mol Med.
  • 2005 Dec;37(6):588-600.
Prostaglandin E2(PGE2), a major product of cyclooxygenase, has been implicated in modulating angiogenesis, vascular function, and inflammatory processes, but the underlying mechanism is not clearly elucidated. We here investigated the...
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Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages

Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB

  • KMID: 1116203
  • Exp Mol Med.
  • 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis...
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Activation of B cells using Schneider 2 cells expressing CD40 ligand for the enhancement of antigen presentation in vitro

Yoon SH, Cho HI, Kim TG

  • KMID: 1116202
  • Exp Mol Med.
  • 2005 Dec;37(6):567-574.
CD40 ligand (CD40L) expressed by activated CD4+ T cells is a family member of membrane bound TNF family ligand and its interaction with CD40 expressed in APC has been shown...
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Early phase of amyloid beta42-induced cytotoxicity in neuronal cells is associated with vacuole formation and enhancement of exocytosis

Liu ML, Hong ST

  • KMID: 1116201
  • Exp Mol Med.
  • 2005 Dec;37(6):559-566.
Amyloid beta (Abeta) neurotoxicity is believed to play a critical role in the pathogenesis of Alzheimer's disease (AD) mainly because of its deposition in AD brain and its neuronal toxicity....
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The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis

Park YR, Choi SC, Lee ST, Kim KS, Chae SC, Chung HT

  • KMID: 1116200
  • Exp Mol Med.
  • 2005 Dec;37(6):553-558.
The eotaxin gene family (eotaxin, eotaxin-2 and eotaxin-3) have been implicated in the recruitment of eosinophils, basophiles and helper T (Th) 2 lymphocytes that is a central aspect of allergic...
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Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis

Choi KH, Lee EB, Yoo CD, Baek HJ, Kang SW, Shin KC, Lee YJ, Kim HA, Jeon JH, Kim CW, Shin DM, Kim IG, Son YW

  • KMID: 1116199
  • Exp Mol Med.
  • 2005 Dec;37(6):546-552.
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to...
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Role of gamma-aminobutyric acid B (GABA B) receptors in the regulation of kainic acid-induced cell death in mouse hippocampus

Lee HK, Seo YJ, Choi SS, Kwon MS, Shim EJ, Lee JY, Suh HW

  • KMID: 1116198
  • Exp Mol Med.
  • 2005 Dec;37(6):533-545.
Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morphological damage of hippocampus expecially concentrated on the CA3 pyramidal neurons. In...
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Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells

Park H, Park OJ, Shin J, Choi Y

  • KMID: 1116197
  • Exp Mol Med.
  • 2005 Dec;37(6):524-532.
Receptor activator of NFkappaB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial substances,...
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Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice

Chae HY, Lee BW, Oh SH, Ahn YR, Chung JH, Min YK, Lee MS, Lee MK, Kim KW

  • KMID: 1116196
  • Exp Mol Med.
  • 2005 Dec;37(6):513-523.
Hypoxic damage is one of the major causes of islet graft failure and VEGF is known to play a crucial role in revascularization. To address the effectiveness of a cationic...
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