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Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata

Lee KH, Huh JW, Choi MM, Yoon SY, Yang SJ, Hong HN, Cho SW

  • KMID: 1093472
  • Exp Mol Med.
  • 2005 Aug;37(4):371-377.
When treated with protopine and alkalized extracts of the tuber of Corydalis ternata for one year, significant decrease in glutamate level and increase in glutamate dehydrogenase (GDH) activity was observed...
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Development of an angiogenesis-focused cDNA chip and validation of its functionality

Shim JS, Lee HK, Park HM, Kim JO, Kim EK, Hwang KH, Kim KT, Park SW, Lee JH, Kwon HJ

  • KMID: 1093471
  • Exp Mol Med.
  • 2005 Aug;37(4):365-370.
DNA chip has been used as a powerful tool to study the genetic reprogramming of cells and its link to cellular phenotype such as angiogenesis. To evaluate the angiogenesis related...
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Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells

Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM

  • KMID: 1093470
  • Exp Mol Med.
  • 2005 Aug;37(4):353-364.
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control...
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Methyl gallate and chemicals structurally related tomethyl gallate protect human umbilical vein endothelial cells from oxidative stress

Whang WK, Park HS, Ham IH, Oh M, Namkoong H, Kim HK, Hwang DW, Hur SY, Kim TE, Park YG, Kim JR, Kim JW

  • KMID: 1093469
  • Exp Mol Med.
  • 2005 Aug;37(4):343-352.
Methyl gallate (meGAL) is known as one of major antioxidants. To investigate whether meGAL protects human cells from oxidative stress, meGAL extracted from Korean medicinal plant, Cercis chinensis leaves, was...
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Cell cycle protein profile of the hepatic stellate cells (HSCs) in dimethylnitrosamine-induced rat hepatic fibrosis

Kim MR, Kim HS, Lee MS, Lee MJ, Jang JJ

  • KMID: 1093468
  • Exp Mol Med.
  • 2005 Aug;37(4):335-342.
Cell cycle regulating proteins are known to have close relation with the proliferation of the mammalian cells. In injured liver, the number of HSCs is increased from proliferation. However, the...
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beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macro phages by suppressing redox-based NF-kappaB activation

Bai SK, Lee SJ, Na HJ, Ha KS, Han JA, Lee H, Kwon YG, Chung CK, Kim YM

  • KMID: 1093467
  • Exp Mol Med.
  • 2005 Aug;37(4):323-334.
beta-Carotene has shown antioxidant and antiinflammatory activities; however, its molecular mechanism has not been clearly defined. We examined in vitro and in vivo regulatory function of beta-carotene on the production...
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Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart

Fauchon MA, Pell TJ, Baxter GF, Yellon DM, Latchman D, Hubank MF, Mayn LV

  • KMID: 1093466
  • Exp Mol Med.
  • 2005 Aug;37(4):311-322.
Preconditioning of the myocardium rapidly induces a number of transcription factors, which are likely to be responsible for a cascade of transcriptional changes underlying the development of delayed adaptation. Identifying...
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Iron chelator inducesMIP-3alpha/CCL20 in human intestinal epithelial cells: implication for triggeringmucosal adaptive immunity

Lee HJ, Choi SC, Choi EY, Lee MH, Seo GS, Kim EC, Yang BJ, Lee MS, Shin YI, Park KI, Jun CD

  • KMID: 1093465
  • Exp Mol Med.
  • 2005 Aug;37(4):297-310.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs). Microarray-based gene...
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Inhibitory effects of epigallocatechin gallate on compound 48/80-inducedmast cell activation and passive cutaneous anaphylaxis

Li GZ, Chai OH, Song CH

  • KMID: 1093464
  • Exp Mol Med.
  • 2005 Aug;37(4):290-296.
Epigallocatechin gallate (EGCG) is a principle phenolic antioxidant found in a variety of plants, including green and black tea. The anti-allergic effect of EGCG is unknown. The purpose of this...
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Ionizing radiation induces blockade of c-Jun N-terminal kinasedependent cell death pathway in amanner correlated with p21Cip/WAF1 induction in primary cultured normal human fibroblasts

Cho ES, Lee SB, Bae IH, Lee YS, Lee SJ, Um HD

  • KMID: 1093463
  • Exp Mol Med.
  • 2005 Aug;37(4):282-289.
During radiotherapy of cancer, neighboring normal cells may receive sub-lethal doses of radiation. To investigate whether such low levels of radiation modulate normal cell responses to death stimuli, primary cultured...
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Hypermethylation of the RUNX3 gene in hepatocellular carcinoma

Park WS, Cho YG, Kim CJ, Song JH, Lee YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY

  • KMID: 1093462
  • Exp Mol Med.
  • 2005 Aug;37(4):276-281.
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. Recently, RUNX3 gene, one of TGF-beta-Smads signaling transduction pathway genes, showed strong tumor-suppressor...
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In vivo targeting of ERGpotassiumchannels inmice and dogs by a positron-emitting analogue of fluoroclofilium

Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann , Herdering , Yu KH

  • KMID: 1093461
  • Exp Mol Med.
  • 2005 Aug;37(4):269-275.
The antiarrhythmic clofilium is an efficient blocker of hERG1 potassium channels that are strongly expressed in the heart. Therefore, derivatives of clofilium that emit positrons might be useful tools for...
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Overexpression of SOX9 in mouse embryonic stem cells directs the immediate chondrogenic commitment

Kim JH, Do HJ, Yang HM, Oh JH, Choi SJ, Kim DK, Cha KY, Chung HM

  • KMID: 1093460
  • Exp Mol Med.
  • 2005 Aug;37(4):261-268.
Mouse embryonic stem (mES) cells are capable of undergoing chondrogenesis in vitro. To enhance this process, the human SOX9 (hSOX9) cDNA was delivered into mES cells and the clones overexpressing...
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