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HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1

Shin JY, Hur W, Wang JS, Jang JW, Kim CW, Bae SH, Jang SK, Yang SH, Sung YC, Kwon OJ, Yoon SK

  • KMID: 755753
  • Exp Mol Med.
  • 2005 Apr;37(2):138-145.
Liver cirrhosis is one of the major complications of hepatitis C virus (HCV) infection, but the mechanisms underlying HCV-related fibrogenesis are still not clear. Although the roles of HCV core...
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Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro

Hur JM, Shim JS, Jung HJ, Kwon HJ

  • KMID: 755752
  • Exp Mol Med.
  • 2005 Apr;37(2):133-137.
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of...
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Common interleukin 10 polymorphism associated with decreased risk of tuberculosis

Shin HD, Park BL, Kim LH, Cheong HS, Lee IH, Park SK

  • KMID: 755751
  • Exp Mol Med.
  • 2005 Apr;37(2):128-132.
Interleukin 10 (IL10) is a powerful TH2-cell cytokine that inhibits lymphocyte replication and secretion of inflammatory cytokines. The genetic associations of polymorphisms in IL10 with clinical manifestations of tuberculosis (TB)...
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In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry

Song JW, Song KJ, Baek LJ, Frost B, Poncz M, Park KS

  • KMID: 755750
  • Exp Mol Med.
  • 2005 Apr;37(2):121-127.
Binding of viruses to cell surface molecules is an essential step in viral infection. In vitro studies suggested that the alpha v beta3 integrin receptor is the epithelial cell receptor...
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Antitumor activity of spinasterol isolated from Pueraria roots

Jeon GC, Park MS, Yoon DY, Shin CH, Sin HS, Um SJ

  • KMID: 755749
  • Exp Mol Med.
  • 2005 Apr;37(2):111-120.
We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenating folk medicine in Thailand and China. Dried, powdered plant...
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Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter

Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH

  • KMID: 755748
  • Exp Mol Med.
  • 2005 Apr;37(2):101-110.
In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2...
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Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells

Jung SY, Kwak JO, Kim HW, Kim DS, Ryu SD, Ko CB, Cha SH

  • KMID: 755747
  • Exp Mol Med.
  • 2005 Apr;37(2):91-100.
The calcium sensing receptor (CaSR) plays an important role for sensing local changes in the extracellular calcium concentration ([Ca2+]o) in bone remodeling. Although the function of CaSR is known, the...
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Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer

Lee SA, Lee KM, Park WY, Kim B, Nam J, Yoo KY, Noh DY, Ahn SH, Hirvonen A, Kang D

  • KMID: 755746
  • Exp Mol Med.
  • 2005 Apr;37(2):86-90.
To evaluate the relationship of genetic polymorphisms of ERCC2 and ERCC4 genes, both involved in nucleotide excision repair (NER), and the risk of breast cancer, a hospital-based case-control study was...
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CD137 induces adhesion and cytokine production in human monocytic THP-1 cells

Choi JW, Lee HW, Roh GS, Kim HH, Kwack KB

  • KMID: 755745
  • Exp Mol Med.
  • 2005 Apr;37(2):78-85.
CD137, which is expressed on activated T cells, plays a critical role in inflammatory responses. However, the exact role that CD137 plays in monocytes is not fully known. Here we...
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Analysis of the factors affecting the accuracy of detection for single base alterations by oligonucleotide microarray

Liu S, Li Y, Fu X, Qiu M, Jiang B, Wu H, Li R, Mao Y, Xie Y

  • KMID: 755744
  • Exp Mol Med.
  • 2005 Apr;37(2):71-77.
The oligonucleotide microarray, a high-throughput polymorphism detection technology, holds great promise for the characterization of complex genetic variance. To achieve greater sensitivity and specificity for it to be an effective...
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